BACKGROUND: Aim of this study was to compare the thyroidal status of mothers to children with and without congenital malformations (CM). METHODS: We examined 129 mothers of newborns with CM and 228 mothers without CM. The assessment included particular history, physical examination, thyroid ultrasonography, fT4, TSH, and anti-TPO measurement of mothers and comparison to birth proportions of newborns. RESULTS: The total volume of the thyroid gland and anti-TPO levels were significantly higher in mothers of the group with CM (p < 0.001 and p < 0.01, respectively). The birth weight and length were significantly lower in the group with congenital malformation when compared to controls (p < 0.0001 and p < 0.001, respectively). CONCLUSIONS: Based on the results of our study, we suggest that thyroid diseases of a mother might participate in congenital malformations of their newborn, although no direct association between thyroid autoantibodies and congenital malformations has been described as of yet.
BACKGROUND: Aim of this study was to compare the thyroidal status of mothers to children with and without congenital malformations (CM). METHODS: We examined 129 mothers of newborns with CM and 228 mothers without CM. The assessment included particular history, physical examination, thyroid ultrasonography, fT4, TSH, and anti-TPO measurement of mothers and comparison to birth proportions of newborns. RESULTS: The total volume of the thyroid gland and anti-TPO levels were significantly higher in mothers of the group with CM (p < 0.001 and p < 0.01, respectively). The birth weight and length were significantly lower in the group with congenital malformation when compared to controls (p < 0.0001 and p < 0.001, respectively). CONCLUSIONS: Based on the results of our study, we suggest that thyroid diseases of a mother might participate in congenital malformations of their newborn, although no direct association between thyroid autoantibodies and congenital malformations has been described as of yet.
Authors: T Bjoro; J Holmen; O Krüger; K Midthjell; K Hunstad; T Schreiner; L Sandnes; H Brochmann Journal: Eur J Endocrinol Date: 2000-11 Impact factor: 6.664
Authors: H Julkunen; R Kaaja; M K Siren; C Mack; S McCready; H Holthöfer; P Kurki; P Maddison Journal: Semin Arthritis Rheum Date: 1998-10 Impact factor: 5.532
Authors: X Y Cao; X M Jiang; Z H Dou; M A Rakeman; M L Zhang; K O'Donnell; T Ma; K Amette; N DeLong; G R DeLong Journal: N Engl J Med Date: 1994-12-29 Impact factor: 91.245
Authors: A Stagnaro-Green; S H Roman; R H Cobin; E el-Harazy; S Wallenstein; T F Davies Journal: J Clin Endocrinol Metab Date: 1992-03 Impact factor: 5.958