Literature DB >> 20736957

Cerebral 5-HT2A receptor and serotonin transporter binding in humans are not affected by the val66met BDNF polymorphism status or blood BDNF levels.

Anders Bue Klein1, Viktorija Trajkovska, David Erritzoe, Steven Haugbol, Jacob Madsen, William Baaré, Susana Aznar, Gitte M Knudsen.   

Abstract

Recent studies have proposed an interrelation between the brain-derived neurotrophic factor (BDNF) val66met polymorphism and the serotonin system. In this study, we investigated whether the BDNF val66met polymorphism or blood BDNF levels are associated with cerebral 5-hydroxytryptamine 2A (5-HT(2A)) receptor or serotonin transporter (SERT) binding in healthy subjects. No statistically significant differences in 5-HT(2A) receptor or SERT binding were found between the val/val and met carriers, nor were blood BDNF values associated with SERT binding or 5-HT(2A) receptor binding. In conclusion, val66met BDNF polymorphism status is not associated with changes in the serotonergic system. Moreover, BDNF levels in blood do not correlate with either 5-HT(2A) or SERT binding.

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Year:  2010        PMID： 20736957      PMCID： PMC3023937          DOI： 10.1038/jcbfm.2010.114

Source DB:  PubMed          Journal:  J Cereb Blood Flow Metab        ISSN： 0271-678X            Impact factor:   6.200


  37 in total

1.  Integrated software for the analysis of brain PET/SPECT studies with partial-volume-effect correction.

Authors:  Mario Quarantelli; Karim Berkouk; Anna Prinster; Brigitte Landeau; Claus Svarer; Laszlo Balkay; Bruno Alfano; Arturo Brunetti; Jean-Claude Baron; Marco Salvatore
Journal:  J Nucl Med       Date:  2004-02       Impact factor: 10.057

2.  BDNF downregulates 5-HT(2A) receptor protein levels in hippocampal cultures.

Authors:  V Trajkovska; M A Santini; A B Marcussen; M S Thomsen; H H Hansen; J D Mikkelsen; L Arneberg; M Kokaia; G M Knudsen; S Aznar
Journal:  Neurochem Int       Date:  2009-06-27       Impact factor: 3.921

Review 3.  New insights into the role of brain-derived neurotrophic factor in synaptic plasticity.

Authors:  Emily G Waterhouse; Baoji Xu
Journal:  Mol Cell Neurosci       Date:  2009-07-03       Impact factor: 4.314

4.  Brain serotonin 2A receptor binding: relations to body mass index, tobacco and alcohol use.

Authors:  D Erritzoe; V G Frokjaer; S Haugbol; L Marner; C Svarer; K Holst; W F C Baaré; P M Rasmussen; J Madsen; O B Paulson; G M Knudsen
Journal:  Neuroimage       Date:  2009-02-05       Impact factor: 6.556

5.  The BDNF val66met polymorphism affects activity-dependent secretion of BDNF and human memory and hippocampal function.

Authors:  Michael F Egan; Masami Kojima; Joseph H Callicott; Terry E Goldberg; Bhaskar S Kolachana; Alessandro Bertolino; Eugene Zaitsev; Bert Gold; David Goldman; Michael Dean; Bai Lu; Daniel R Weinberger
Journal:  Cell       Date:  2003-01-24       Impact factor: 41.582

6.  Genetic variation in brain-derived neurotrophic factor is associated with serotonin transporter but not serotonin-1A receptor availability in men.

Authors:  Susanne Henningsson; Jacqueline Borg; Johan Lundberg; Jessica Bah; Mats Lindström; Erik Ryding; Hristina Jovanovic; Tomoyuki Saijo; Makoto Inoue; Ingmar Rosén; Lil Träskman-Bendz; Lars Farde; Elias Eriksson
Journal:  Biol Psychiatry       Date:  2009-06-05       Impact factor: 13.382

7.  BDNF Val66Met is associated with introversion and interacts with 5-HTTLPR to influence neuroticism.

Authors:  Antonio Terracciano; Toshiko Tanaka; Angelina R Sutin; Barbara Deiana; Lenuta Balaci; Serena Sanna; Nazario Olla; Andrea Maschio; Manuela Uda; Luigi Ferrucci; David Schlessinger; Paul T Costa
Journal:  Neuropsychopharmacology       Date:  2009-12-30       Impact factor: 7.853

8.  Familial risk for mood disorder and the personality risk factor, neuroticism, interact in their association with frontolimbic serotonin 2A receptor binding.

Authors:  Vibe G Frokjaer; Maj Vinberg; David Erritzoe; William Baaré; Klaus Kähler Holst; Erik Lykke Mortensen; Haroon Arfan; Jacob Madsen; Terry L Jernigan; Lars Vedel Kessing; Gitte Moos Knudsen
Journal:  Neuropsychopharmacology       Date:  2009-12-30       Impact factor: 7.853

9.  Interactions between BDNF Val66Met polymorphism and early life stress predict brain and arousal pathways to syndromal depression and anxiety.

Authors:  J M Gatt; C B Nemeroff; C Dobson-Stone; R H Paul; R A Bryant; P R Schofield; E Gordon; A H Kemp; L M Williams
Journal:  Mol Psychiatry       Date:  2009-01-20       Impact factor: 15.992

10.  Quantification of 5-HT2A receptors in the human brain using [18F]altanserin-PET and the bolus/infusion approach.

Authors:  Lars H Pinborg; Karen H Adams; Claus Svarer; Søren Holm; Steen G Hasselbalch; Steven Haugbøl; Jacob Madsen; Gitte M Knudsen
Journal:  J Cereb Blood Flow Metab       Date:  2003-08       Impact factor: 6.200
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  5 in total

1.  BDNF Val66met and 5-HTTLPR polymorphisms predict a human in vivo marker for brain serotonin levels.

Authors:  Patrick M Fisher; Klaus K Holst; Dea Adamsen; Anders Bue Klein; Vibe G Frokjaer; Peter S Jensen; Claus Svarer; Nic Gillings; William F C Baare; Jens D Mikkelsen; Gitte M Knudsen
Journal:  Hum Brain Mapp       Date:  2014-09-13       Impact factor: 5.038

2.  Exploring the impact of BDNF Val66Met genotype on serotonin transporter and serotonin-1A receptor binding.

Authors:  Christoph Kraus; Pia Baldinger; Christina Rami-Mark; Gregor Gryglewski; Gregor Gryglewsky; Georg S Kranz; Daniela Haeusler; Andreas Hahn; Wolfgang Wadsak; Markus Mitterhauser; Dan Rujescu; Siegfried Kasper; Rupert Lanzenberger
Journal:  PLoS One       Date:  2014-09-04       Impact factor: 3.240

3.  BDNF val66met association with serotonin transporter binding in healthy humans.

Authors:  P M Fisher; B Ozenne; C Svarer; D Adamsen; S Lehel; W F C Baaré; P S Jensen; G M Knudsen
Journal:  Transl Psychiatry       Date:  2017-02-14       Impact factor: 6.222

Review 4.  Brain-Derived Neurotrophic Factor and Antidepressive Effect of Electroconvulsive Therapy: Systematic Review and Meta-Analyses of the Preclinical and Clinical Literature.

Authors:  M Polyakova; M L Schroeter; B M Elzinga; S Holiga; P Schoenknecht; E R de Kloet; M L Molendijk
Journal:  PLoS One       Date:  2015-11-03       Impact factor: 3.240

5.  Epistasis of HTR1A and BDNF risk genes alters cortical 5-HT1A receptor binding: PET results link genotype to molecular phenotype in depression.

Authors:  Alexander Kautzky; Gregory M James; Cecile Philippe; Pia Baldinger-Melich; Christoph Kraus; Georg S Kranz; Thomas Vanicek; Gregor Gryglewski; Annette M Hartmann; Andreas Hahn; Wolfgang Wadsak; Markus Mitterhauser; Dan Rujescu; Siegfried Kasper; Rupert Lanzenberger
Journal:  Transl Psychiatry       Date:  2019-01-16       Impact factor: 6.222
  5 in total

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