BACKGROUND: Neonatal alloimmune-mediated neutropenia (NAIN) due to maternal alloantibodies directed against one of the human neutrophil antigens (HNAs) can cause severe infections. NAIN has been described as caused by antibodies against HNA-1a, -b, -c, -2a, -3a, or -4a, but not by antibodies against HNA-5a. RESULTS: Blood from a 3-week-old newborn and from his parents was sent to our laboratory because of suspicion of NAIN. Granulocyte-specific antibodies were present in the maternal antiserum and reactive with the paternal granulocytes. The specificity of the maternal alloantibodies was shown to be anti-HNA-5a by the monoclonal antibody immobilization of granulocyte antigens assay. The mother was genotyped HNA-5a negative, and the father was genotyped homozygous HNA-5a positive. CONCLUSION: We identified a first case of NAIN due to maternal alloantibodies against HNA-5a.
BACKGROUND: Neonatal alloimmune-mediated neutropenia (NAIN) due to maternal alloantibodies directed against one of the human neutrophil antigens (HNAs) can cause severe infections. NAIN has been described as caused by antibodies against HNA-1a, -b, -c, -2a, -3a, or -4a, but not by antibodies against HNA-5a. RESULTS: Blood from a 3-week-old newborn and from his parents was sent to our laboratory because of suspicion of NAIN. Granulocyte-specific antibodies were present in the maternal antiserum and reactive with the paternal granulocytes. The specificity of the maternal alloantibodies was shown to be anti-HNA-5a by the monoclonal antibody immobilization of granulocyte antigens assay. The mother was genotyped HNA-5a negative, and the father was genotyped homozygous HNA-5a positive. CONCLUSION: We identified a first case of NAIN due to maternal alloantibodies against HNA-5a.
Authors: JoonHo Lee; Roberto Romero; Yi Xu; Jung-Sun Kim; Ji Young Park; Juan Pedro Kusanovic; Tinnakorn Chaiworapongsa; Sonia S Hassan; Chong Jai Kim Journal: Am J Reprod Immunol Date: 2011-09-27 Impact factor: 3.886
Authors: Siti M Manaf; Hanis Z A NurWaliyuddin; Sundararajulu Panneerchelvam; Zainuddin Zafarina; Mohd N Norazmi; Geoffrey K Chambers; Hisham A Edinur Journal: Blood Transfus Date: 2015-04-20 Impact factor: 3.443
Authors: Zuopeng Wu; Rong Liang; Thomas Ohnesorg; Vicky Cho; Wesley Lam; Walter P Abhayaratna; Paul A Gatenby; Chandima Perera; Yafei Zhang; Belinda Whittle; Andrew Sinclair; Christopher C Goodnow; Matthew Field; T Daniel Andrews; Matthew C Cook Journal: PLoS Genet Date: 2016-05-26 Impact factor: 5.917