CONCLUSION: Intratympanic administration of prednisolone at a dose of 62.5 mg/ml performed every day for 3 consecutive days is more efficacious than the therapeutic approaches described so far in the literature. OBJECTIVES: The aim of the study was to evaluate the overall success rate, morbidity, and prognostic factors of a new protocol of intratympanic steroid administration as a means of primary therapy for idiopathic sensorineural hearing loss. METHODS: Overall, 34 patients presenting sudden unilateral sensorineural hearing loss of at least 30 dB over three frequencies that had developed within 72 h were treated once a day for 3 consecutive days with a single intratympanic injection of prednisone diluted in saline solution. RESULTS: Following intratympanic therapy with prednisone, 16 patients (47%) reported complete recovery of sudden sensorineural hearing loss, with a pure tone average that returned within 25 dB; 11 patients (32.3%) showed improvement in hearing of more than 30 dB; 4 patients presented improvement in pure-tone average between 10 and 30 dB. Only three patients failed to improve following intratympanic injection.
CONCLUSION: Intratympanic administration of prednisolone at a dose of 62.5 mg/ml performed every day for 3 consecutive days is more efficacious than the therapeutic approaches described so far in the literature. OBJECTIVES: The aim of the study was to evaluate the overall success rate, morbidity, and prognostic factors of a new protocol of intratympanic steroid administration as a means of primary therapy for idiopathic sensorineural hearing loss. METHODS: Overall, 34 patients presenting sudden unilateral sensorineural hearing loss of at least 30 dB over three frequencies that had developed within 72 h were treated once a day for 3 consecutive days with a single intratympanic injection of prednisone diluted in saline solution. RESULTS: Following intratympanic therapy with prednisone, 16 patients (47%) reported complete recovery of sudden sensorineural hearing loss, with a pure tone average that returned within 25 dB; 11 patients (32.3%) showed improvement in hearing of more than 30 dB; 4 patients presented improvement in pure-tone average between 10 and 30 dB. Only three patients failed to improve following intratympanic injection.
Authors: Petros V Vlastarakos; George Papacharalampous; Paul Maragoudakis; George Kampessis; Nicholas Maroudias; Dimitrios Candiloros; Thomas P Nikolopoulos Journal: Eur Arch Otorhinolaryngol Date: 2011-08-19 Impact factor: 2.503
Authors: M Shimoji; B Ramaswamy; M I Shukoor; P Benhal; A Broda; S Kulkarni; P Malik; B McCaffrey; J-F Lafond; A Nacev; I N Weinberg; B Shapiro; D A Depireux Journal: Eur J Pharm Sci Date: 2018-06-19 Impact factor: 4.384
Authors: G Attanasio; E Covelli; L Cagnoni; E Masci; D Ferraro; P Mancini; E Alessandri; G Cartocci; R Filipo; M Rocco Journal: Acta Otorhinolaryngol Ital Date: 2015-10 Impact factor: 2.124
Authors: Monique Antunes de Souza Chelminski Barreto; Aleluia Lima Losno Ledesma; Carlos Augusto Costa Pires de Oliveira; Fayez Bahmad Journal: Braz J Otorhinolaryngol Date: 2015-11-06