Literature DB >> 20734929

Cytotoxic activity of quassinoids from Eurycoma longifolia.

Katsunori Miyake1, Feng Li, Yasuhiro Tezuka, Suresh Awale, Shigetoshi Kadota.   

Abstract

Twenty-four quassinoids isolated from Eurycoma longifolia Jack were investigated for their cytotoxicity against a panel of four different cancer cell lines, which includes three murine cell lines [colon 26-L5 carcinoma (colon 26-L5), B16-BL6 melanoma (B16-BL6), Lewis lung carcinoma (LLC)] and a human lung A549 adenocarcinoma (A549) cell line. Among the tested compounds, eurycomalactone (9) displayed the most potent activity against all the tested cell lines; colon 26-L5 (IC50 = 0.70 microM), B16-BL6 (IC50 = 0.59 microM), LLC (IC50 = 0.78 microM), and A549 (IC50 = 0.73 microM). These activities were comparable to clinically used anticancer agent doxorubicin (colon 26-L5, IC50 = 0.76 microM; B16-BL6, IC50 = 0.86 microM; LLC, IC50 = 0.80 microM; A549, IC50 = 0.66 microM).

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Year:  2010        PMID： 20734929

Source DB:  PubMed          Journal:  Nat Prod Commun        ISSN： 1555-9475            Impact factor:   0.986


  6 in total

1.  Glaucarubulone glucoside from Castela macrophylla suppresses MCF-7 breast cancer cell growth and attenuates benzo[a]pyrene-mediated CYP1A gene induction.

Authors:  Simone A M Badal; Malyn M Asuncion Valenzuela; Dain Zylstra; George Huang; Pallavi Vendantam; Sheena Francis; Ashley Quitugua; Louisa H Amis; Willie Davis; Tzuen-Rong J Tzeng; Helen Jacobs; David J Gangemi; Greg Raner; Leah Rowland; Jonathan Wooten; Petreena Campbell; Eileen Brantley; Rupika Delgoda
Journal:  J Appl Toxicol       Date:  2017-01-31       Impact factor: 3.446

2.  The in vitro and in vivo anti-cancer activities of a standardized quassinoids composition from Eurycoma longifolia on LNCaP human prostate cancer cells.

Authors:  Kind Leng Tong; Kit Lam Chan; Sazaly AbuBakar; Bin Seng Low; Hai Qiu Ma; Pooi Fong Wong
Journal:  PLoS One       Date:  2015-03-31       Impact factor: 3.240

3.  Inactivation of AKT/NF‑κB signaling by eurycomalactone decreases human NSCLC cell viability and improves the chemosensitivity to cisplatin.

Authors:  Nahathai Dukaew; Kongthawat Chairatvit; Pornsiri Pitchakarn; Arisa Imsumran; Jirarat Karinchai; Wirote Tuntiwechapikul; Ariyaphong Wongnoppavich
Journal:  Oncol Rep       Date:  2020-07-31       Impact factor: 3.906

4.  Enhancement of Radiosensitivity by Eurycomalactone in Human NSCLC Cells Through G₂/M Cell Cycle Arrest and Delayed DNA Double-Strand Break Repair.

Authors:  Nahathai Dukaew; Teruaki Konishi; Kongthawat Chairatvit; Narongchai Autsavapromporn; Noppamas Soonthornchareonnon; Ariyaphong Wongnoppavich
Journal:  Oncol Res       Date:  2019-11-14       Impact factor: 5.574

5.  The In Vitro Anti-Cancer Activities and Mechanisms of Action of 9-Methoxycanthin-6-one from Eurycoma longifolia in Selected Cancer Cell Lines.

Authors:  Nurhanan Murni Yunos; Nor Datiakma Mat Amin; Muhammad Haffiz Jauri; Sui Kiong Ling; Nor Hasnida Hassan; Nor Jannah Sallehudin
Journal:  Molecules       Date:  2022-01-18       Impact factor: 4.411

6.  Evaluation of Acute 13-Week Subchronic Toxicity and Genotoxicity of the Powdered Root of Tongkat Ali (Eurycoma longifolia Jack).

Authors:  Ching-Hao Li; Jiunn-Wang Liao; Po-Lin Liao; Wei-Kuang Huang; Ling-Shan Tse; Cheng-Hui Lin; Jaw-Jou Kang; Yu-Wen Cheng
Journal:  Evid Based Complement Alternat Med       Date:  2013-08-25       Impact factor: 2.629
  6 in total

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