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Literature DB >> 20733581

Bariatric surgery in a patient with complete MC4R deficiency.

I R Aslan¹, S A Ranadive, B A Ersoy, S J Rogers, R H Lustig, C Vaisse.

Abstract

Bariatric surgery is often successful for treatment of severe obesity. The mechanisms of weight loss after bariatric surgery and the role of central energy homeostatic pathways in this weight loss process are not well understood. The study of individuals with complete loss of function of genes important in the leptin-melanocortin system may help establish the significance of these pathways for weight loss after bariatric surgery. We describe the outcome of bariatric surgery in an adolescent with compound heterozygosity and complete functional loss of both alleles of the melanocortin 4 receptor (MC4R). The patient underwent laparoscopic adjustable gastric banding and truncal vagotomy at years of age, which resulted in initial, but not long-term weight loss. Our experience with this patient suggests that complete MC4R deficiency impairs response to gastric banding and results in poor weight loss after this surgery.

Entities: CellLine Chemical Disease Gene Mutation Species

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Year: 2010 PMID： 20733581 PMCID： PMC4648366 DOI： 10.1038/ijo.2010.168

Source DB: PubMed Journal: Int J Obes (Lond) ISSN： 0307-0565 Impact factor: 5.095

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Review 1. Central nervous system control of food intake.

Authors: M W Schwartz; S C Woods; D Porte; R J Seeley; D G Baskin
Journal: Nature Date: 2000-04-06 Impact factor: 49.962

Review 2. Interactions between gut peptides and the central melanocortin system in the regulation of energy homeostasis.

Authors: Kate L J Ellacott; Ilia G Halatchev; Roger D Cone
Journal: Peptides Date: 2005-11-22 Impact factor: 3.750

3. Melanocortin 4 receptor mutations in a large cohort of severely obese adults: prevalence, functional classification, genotype-phenotype relationship, and lack of association with binge eating.

Authors: Cecile Lubrano-Berthelier; Beatrice Dubern; Jean-Marc Lacorte; Franck Picard; Astrid Shapiro; Sumei Zhang; Sandrine Bertrais; Serge Hercberg; Arnaud Basdevant; Karine Clement; Christian Vaisse
Journal: J Clin Endocrinol Metab Date: 2006-02-28 Impact factor: 5.958

4. Laparoscopic adjustable gastric banding in severely obese adolescents: a randomized trial.

Authors: Paul E O'Brien; Susan M Sawyer; Cheryl Laurie; Wendy A Brown; Stewart Skinner; Friederike Veit; Eldho Paul; Paul R Burton; Melanie McGrice; Margaret Anderson; John B Dixon
Journal: JAMA Date: 2010-02-10 Impact factor: 56.272

5. Meta-analysis: surgical treatment of obesity.

Authors: Melinda A Maggard; Lisa R Shugarman; Marika Suttorp; Margaret Maglione; Harvey J Sugerman; Harvey J Sugarman; Edward H Livingston; Ninh T Nguyen; Zhaoping Li; Walter A Mojica; Lara Hilton; Shannon Rhodes; Sally C Morton; Paul G Shekelle
Journal: Ann Intern Med Date: 2005-04-05 Impact factor: 25.391

Review 6. Peripheral and central signals in the control of eating in normal, obese and binge-eating human subjects.

Authors: Per M Hellström; Allan Geliebter; Erik Näslund; Peter T Schmidt; Eric K Yahav; Sami A Hashim; Martin R Yeomans
Journal: Br J Nutr Date: 2004-08 Impact factor: 3.718

7. Localization of the melanocortin-4 receptor (MC4-R) in neuroendocrine and autonomic control circuits in the brain.

Authors: K G Mountjoy; M T Mortrud; M J Low; R B Simerly; R D Cone
Journal: Mol Endocrinol Date: 1994-10

Review 8. Lessons from extreme human obesity: monogenic disorders.

Authors: Sayali A Ranadive; Christian Vaisse
Journal: Endocrinol Metab Clin North Am Date: 2008-09 Impact factor: 4.741

9. A comparison of laparoscopic adjustable gastric banding in adolescents and adults.

Authors: K Dolan; G Fielding
Journal: Surg Endosc Date: 2003-11-21 Impact factor: 4.584

10. Intracellular retention is a common characteristic of childhood obesity-associated MC4R mutations.

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Journal: Hum Mol Genet Date: 2003-01-15 Impact factor: 6.150

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Journal: Am J Physiol Endocrinol Metab Date: 2012-04-24 Impact factor: 4.310

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5. Presence of CC Genotype for rs17773430 Could Affect the Percentage of Excess Weight Loss 1 Year After Bariatric Surgery: Tehran Obesity Treatment Study (TOTS).

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6. The MC4R(I251L) allele is associated with better metabolic status and more weight loss after gastric bypass surgery.

Authors: Uyenlinh L Mirshahi; Christopher D Still; Kathryn K Masker; Glenn S Gerhard; David J Carey; Tooraj Mirshahi
Journal: J Clin Endocrinol Metab Date: 2011-10-05 Impact factor: 5.958

7. Hyperphagia: current concepts and future directions proceedings of the 2nd international conference on hyperphagia.

Authors: Steven B Heymsfield; Nicole M Avena; Leslie Baier; Phillip Brantley; George A Bray; Lisa C Burnett; Merlin G Butler; Daniel J Driscoll; Dieter Egli; Joel Elmquist; Janice L Forster; Anthony P Goldstone; Linda M Gourash; Frank L Greenway; Joan C Han; James G Kane; Rudolph L Leibel; Ruth J F Loos; Ann O Scheimann; Christian L Roth; Randy J Seeley; Val Sheffield; Maïthé Tauber; Christian Vaisse; Liheng Wang; Robert A Waterland; Rachel Wevrick; Jack A Yanovski; Andrew R Zinn
Journal: Obesity (Silver Spring) Date: 2014-02 Impact factor: 5.002