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Literature DB >> 20731374

Direct renin inhibitors as a new therapy for hypertension.

Randy L Webb¹, Nikolaus Schiering, Richard Sedrani, Jürgen Maibaum.

Abstract

Entities: Disease Gene

Mesh：

Substances：

Year: 2010 PMID： 20731374 DOI： 10.1021/jm901885s

Source DB: PubMed Journal: J Med Chem ISSN： 0022-2623 Impact factor: 7.446

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12 in total

1. Grassystatins D-F, Potent Aspartic Protease Inhibitors from Marine Cyanobacteria as Potential Antimetastatic Agents Targeting Invasive Breast Cancer.

Authors: Fatma H Al-Awadhi; Brian K Law; Valerie J Paul; Hendrik Luesch
Journal: J Nat Prod Date: 2017-10-31 Impact factor: 4.050

2. Potent and Selective Inhibitors of Long Chain l-2-Hydroxy Acid Oxidase Reduced Blood Pressure in DOCA Salt-Treated Rats.

Authors: Dinesh A Barawkar; Ashwin Meru; Anish Bandyopadhyay; Abir Banerjee; Anil M Deshpande; Chandrashekhar Athare; Chandrasekhar Koduru; Goraksha Khose; Jayasagar Gundu; Koshu Mahajan; Pradeep Patil; Sachin R Kandalkar; Sanjay Niranjan; Shubhangi Bhosale; Siddhartha De; Sudit Mukhopadhyay; Sumit Chaudhary; Summon Koul; Umesh Singh; Anita Chugh; Venkata P Palle; Kasim A Mookhtiar; Joseph Vacca; Prasun K Chakravarty; Ravi P Nargund; Samuel D Wright; Sophie Roy; Michael P Graziano; Sheo B Singh; Doris Cully; Tian-Quan Cai
Journal: ACS Med Chem Lett Date: 2011-10-07 Impact factor: 4.345

3. Discovery of DS-8108b, a Novel Orally Bioavailable Renin Inhibitor.

Authors: Yuji Nakamura; Teppei Fujimoto; Yasuyuki Ogawa; Chie Sugita; Shojiro Miyazaki; Kazuhiko Tamaki; Mizuki Takahashi; Yumi Matsui; Takahiro Nagayama; Kenichi Manabe; Makoto Mizuno; Noriko Masubuchi; Katsuyoshi Chiba; Takahide Nishi
Journal: ACS Med Chem Lett Date: 2012-08-18 Impact factor: 4.345

4. Discovery of VTP-27999, an Alkyl Amine Renin Inhibitor with Potential for Clinical Utility.

Authors: Lanqi Jia; Robert D Simpson; Jing Yuan; Zhenrong Xu; Wei Zhao; Salvacion Cacatian; Colin M Tice; Joan Guo; Alexey Ishchenko; Suresh B Singh; Zhongren Wu; Brian M McKeever; Yuri Bukhtiyarov; Judith A Johnson; Christopher P Doe; Richard K Harrison; Gerard M McGeehan; Lawrence W Dillard; John J Baldwin; David A Claremon
Journal: ACS Med Chem Lett Date: 2011-08-09 Impact factor: 4.345

5. Design, synthesis and biological evaluation of renin inhibitors guided by simulated annealing of chemical potential simulations.

Authors: Ian S Cloudsdale; John K Dickson; Thomas E Barta; Brian S Grella; Emilie D Smith; John L Kulp; Frank Guarnieri; John L Kulp
Journal: Bioorg Med Chem Date: 2017-05-19 Impact factor: 3.641

6. Discovery of Novel 2-Carbamoyl Morpholine Derivatives as Highly Potent and Orally Active Direct Renin Inhibitors.

Authors: Daisuke Iijima; Hiroshi Sugama; Nobumasa Awai; Yoichi Takahashi; Yuko Togashi; Tohru Takebe; Jianshu Xie; Jingkang Shen; Ying Ke; Hidenori Akatsuka; Takayuki Kawaguchi; Kei Takedomi; Akiko Kashima; Masashi Nishio; Yosuke Inui; Hikaru Yoneda; Guangxin Xia; Toru Iijima
Journal: ACS Med Chem Lett Date: 2022-08-01 Impact factor: 4.632

7. Structure-based design of substituted piperidines as a new class of highly efficacious oral direct Renin inhibitors.

Authors: Takeru Ehara; Osamu Irie; Takatoshi Kosaka; Takanori Kanazawa; Werner Breitenstein; Philipp Grosche; Nils Ostermann; Masaki Suzuki; Shimpei Kawakami; Kazuhide Konishi; Yuko Hitomi; Atsushi Toyao; Hiroki Gunji; Frederic Cumin; Nikolaus Schiering; Trixie Wagner; Dean F Rigel; Randy L Webb; Jürgen Maibaum; Fumiaki Yokokawa
Journal: ACS Med Chem Lett Date: 2014-04-21 Impact factor: 4.345