Literature DB >> 20730210

Reactions of medicinally relevant gold compounds with the C-terminal motif of thioredoxin reductase elucidated by MS analysis.

Alessandro Pratesi1, Chiara Gabbiani, Mauro Ginanneschi, Luigi Messori.   

Abstract

The tetrapeptide Ac-Gly-[Cys-Sec]-Gly-NH(2), reproducing the C-terminal motif of the selenoenzyme thioredoxin reductase, was designed and synthesized, and its reactions with a few medicinally relevant gold(i,iii) compounds investigated by ESI-MS. Remarkably, the main reaction products could be unambiguously identified providing valuable insight into the likely mechanisms of enzyme inhibition by gold compounds.

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Year:  2010        PMID： 20730210     DOI： 10.1039/c0cc01465f

Source DB:  PubMed          Journal:  Chem Commun (Camb)        ISSN： 1359-7345            Impact factor:   6.222


  8 in total

1.  Selective targeting of the cysteine proteome by thioredoxin and glutathione redox systems.

Authors:  Young-Mi Go; James R Roede; Douglas I Walker; Duc M Duong; Nicholas T Seyfried; Michael Orr; Yongliang Liang; Kurt D Pennell; Dean P Jones
Journal:  Mol Cell Proteomics       Date:  2013-08-14       Impact factor: 5.911

2.  Reactivity of the [Au(C^N^C)Cl] complex in the presence of H2O and N-, S- and Se-containing nucleophiles: a DFT study.

Authors:  G Y Sánchez Delgado; D Paschoal; H F Dos Santos
Journal:  J Biol Inorg Chem       Date:  2018-09-12       Impact factor: 3.358

3.  EM23, a natural sesquiterpene lactone, targets thioredoxin reductase to activate JNK and cell death pathways in human cervical cancer cells.

Authors:  Fang-Yuan Shao; Sheng Wang; Hong-Yu Li; Wen-Bo Chen; Guo-Cai Wang; Dong-Lei Ma; Nai Sum Wong; Hao Xiao; Qiu-Ying Liu; Guang-Xiong Zhou; Yao-Lan Li; Man-Mei Li; Yi-Fei Wang; Zhong Liu
Journal:  Oncotarget       Date:  2016-02-09

Review 4.  Metal- and Semimetal-Containing Inhibitors of Thioredoxin Reductase as Anticancer Agents.

Authors:  Valentina Gandin; Aristi P Fernandes
Journal:  Molecules       Date:  2015-07-14       Impact factor: 4.411

Review 5.  Strategies for the Improvement of Metal-Based Chemotherapeutic Treatments.

Authors:  Damiano Cirri; Francesco Bartoli; Alessandro Pratesi; Emma Baglini; Elisabetta Barresi; Tiziano Marzo
Journal:  Biomedicines       Date:  2021-05-04

6.  Antiproliferative effects of two gold(I)-N-heterocyclic carbene complexes in A2780 human ovarian cancer cells: a comparative proteomic study.

Authors:  Francesca Magherini; Tania Fiaschi; Elisa Valocchia; Matteo Becatti; Alessandro Pratesi; Tiziano Marzo; Lara Massai; Chiara Gabbiani; Ida Landini; Stefania Nobili; Enrico Mini; Luigi Messori; Alessandra Modesti; Tania Gamberi
Journal:  Oncotarget       Date:  2018-06-15

7.  Reactions of Medicinal Gold(III) Compounds With Proteins and Peptides Explored by Electrospray Ionization Mass Spectrometry and Complementary Biophysical Methods.

Authors:  Lara Massai; Carlotta Zoppi; Damiano Cirri; Alessandro Pratesi; Luigi Messori
Journal:  Front Chem       Date:  2020-10-21       Impact factor: 5.221

8.  Mechanistic Insights Into the Anticancer Properties of the Auranofin Analog Au(PEt3)I: A Theoretical and Experimental Study.

Authors:  Iogann Tolbatov; Damiano Cirri; Lorella Marchetti; Alessandro Marrone; Cecilia Coletti; Nazzareno Re; Diego La Mendola; Luigi Messori; Tiziano Marzo; Chiara Gabbiani; Alessandro Pratesi
Journal:  Front Chem       Date:  2020-09-18       Impact factor: 5.221
  8 in total

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