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Literature DB >> 20729839

Meiotic kinetochores get pushed aside by a CLS act.

Abstract

Kinetochores link microtubules to DNA and provide force critical for chromosome segregation in mitosis. New data show that kinetochores are not necessary for acentrosomal meiotic chromosome segregation in Caenorhabditis elegans. Instead, CLS-2 (CLASP) generates a mid-zone bundle of microtubules that are suggested to act in pushing the chromosomes apart.

Entities: Chemical Gene Species

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Year: 2010 PMID： 20729839 DOI： 10.1038/ncb0910-849

Source DB: PubMed Journal: Nat Cell Biol ISSN： 1465-7392 Impact factor: 28.824

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References

16 in total

Review 1. The perpetual movements of anaphase.

Authors: Helder Maiato; Mariana Lince-Faria
Journal: Cell Mol Life Sci Date: 2010-03-21 Impact factor: 9.261

2. A kinetochore-independent mechanism drives anaphase chromosome separation during acentrosomal meiosis.

Authors: Julien Dumont; Karen Oegema; Arshad Desai
Journal: Nat Cell Biol Date: 2010-08-22 Impact factor: 28.824

3. The conserved KMN network constitutes the core microtubule-binding site of the kinetochore.

Authors: Iain M Cheeseman; Joshua S Chappie; Elizabeth M Wilson-Kubalek; Arshad Desai
Journal: Cell Date: 2006-12-01 Impact factor: 41.582

4. Differential role of CENP-A in the segregation of holocentric C. elegans chromosomes during meiosis and mitosis.

Authors: Joost Monen; Paul S Maddox; Francie Hyndman; Karen Oegema; Arshad Desai
Journal: Nat Cell Biol Date: 2005-11-06 Impact factor: 28.824

Review 5. The elegans of spindle assembly.

Authors: Thomas Müller-Reichert; Garrett Greenan; Eileen O'Toole; Martin Srayko
Journal: Cell Mol Life Sci Date: 2010-03-26 Impact factor: 9.261

Meiotic kinetochores get pushed aside by a CLS act.

Review 1. The perpetual movements of anaphase.

2. A kinetochore-independent mechanism drives anaphase chromosome separation during acentrosomal meiosis.

3. The conserved KMN network constitutes the core microtubule-binding site of the kinetochore.

4. Differential role of CENP-A in the segregation of holocentric C. elegans chromosomes during meiosis and mitosis.

Review 5. The elegans of spindle assembly.

6. Isolation of the centromere-linked CDC10 gene by complementation in yeast.

Review 7. The 3Ms of central spindle assembly: microtubules, motors and MAPs.

8. Functional analysis of kinetochore assembly in Caenorhabditis elegans.

9. Kinetochore-independent chromosome poleward movement during anaphase of meiosis II in mouse eggs.

10. Loss of KLP-19 polar ejection force causes misorientation and missegregation of holocentric chromosomes.