Literature DB >> 20729634

Ubiquilin at a crossroads in protein degradation pathways.

Cara Rothenberg1, Mervyn J Monteiro.   

Abstract

Ubiquilin proteins are conserved across all eukaryotes and function in the regulation of protein degradation. We found that ubiquilin functions to regulate macroautophagy and that the protein is also a substrate of chaperone-mediated autophagy.

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Year:  2010        PMID： 20729634      PMCID： PMC3359474          DOI： 10.4161/auto.6.7.13118

Source DB:  PubMed          Journal:  Autophagy        ISSN： 1554-8627            Impact factor:   16.016


  1 in total

1.  Ubiquilin functions in autophagy and is degraded by chaperone-mediated autophagy.

Authors:  Cara Rothenberg; Deepa Srinivasan; Leann Mah; Susmita Kaushik; Corrine M Peterhoff; Janet Ugolino; Shengyun Fang; Ana Maria Cuervo; Ralph A Nixon; Mervyn J Monteiro
Journal:  Hum Mol Genet       Date:  2010-06-07       Impact factor: 6.150
  1 in total
  22 in total

1.  GbPDF1 is involved in cotton fiber initiation via the core cis-element HDZIP2ATATHB2.

Authors:  Fenglin Deng; Lili Tu; Jiafu Tan; Yang Li; Yichun Nie; Xianlong Zhang
Journal:  Plant Physiol       Date:  2011-11-28       Impact factor: 8.340

Review 2.  Chaperone-mediated autophagy: machinery, regulation and biological consequences.

Authors:  Wenming Li; Qian Yang; Zixu Mao
Journal:  Cell Mol Life Sci       Date:  2010-10-26       Impact factor: 9.261

3.  The specificity of ubiquitin binding to ubiquilin-1 is regulated by sequences besides its UBA domain.

Authors:  Christine A Harman; Mervyn J Monteiro
Journal:  Biochim Biophys Acta Gen Subj       Date:  2019-06-06       Impact factor: 3.770

4.  Pattern of ubiquilin pathology in ALS and FTLD indicates presence of C9ORF72 hexanucleotide expansion.

Authors:  Johannes Brettschneider; Vivianna M Van Deerlin; John L Robinson; Linda Kwong; Edward B Lee; Yousuf O Ali; Nathaniel Safren; Mervyn J Monteiro; Jon B Toledo; Lauren Elman; Leo McCluskey; David J Irwin; Murray Grossman; Laura Molina-Porcel; Virginia M-Y Lee; John Q Trojanowski
Journal:  Acta Neuropathol       Date:  2012-03-18       Impact factor: 17.088

5.  Ubiquilin-2 (UBQLN2) binds with high affinity to the C-terminal region of TDP-43 and modulates TDP-43 levels in H4 cells: characterization of inhibition by nucleic acids and 4-aminoquinolines.

Authors:  Joel A Cassel; Allen B Reitz
Journal:  Biochim Biophys Acta       Date:  2013-03-27

6.  UBQLN4 recognizes mislocalized transmembrane domain proteins and targets these to proteasomal degradation.

Authors:  Rigel Suzuki; Hiroyuki Kawahara
Journal:  EMBO Rep       Date:  2016-04-22       Impact factor: 8.807

7.  Motor neuron disease, TDP-43 pathology, and memory deficits in mice expressing ALS-FTD-linked UBQLN2 mutations.

Authors:  Nhat T T Le; Lydia Chang; Irina Kovlyagina; Polymnia Georgiou; Nathaniel Safren; Kerstin E Braunstein; Mark D Kvarta; Adam M Van Dyke; Tara A LeGates; Thomas Philips; Brett M Morrison; Scott M Thompson; Adam C Puche; Todd D Gould; Jeffrey D Rothstein; Philip C Wong; Mervyn J Monteiro
Journal:  Proc Natl Acad Sci U S A       Date:  2016-11-09       Impact factor: 11.205

8.  Signature changes in ubiquilin expression in the R6/2 mouse model of Huntington's disease.

Authors:  Nathaniel Safren; Lydia Chang; Kristina M Dziki; Mervyn J Monteiro
Journal:  Brain Res       Date:  2014-12-12       Impact factor: 3.252

Review 9.  Polyubiquitinylation Profile in Down Syndrome Brain Before and After the Development of Alzheimer Neuropathology.

Authors:  Antonella Tramutola; Fabio Di Domenico; Eugenio Barone; Andrea Arena; Alessandra Giorgi; Laura di Francesco; Maria Eugenia Schininà; Raffaella Coccia; Elizabeth Head; D Allan Butterfield; Marzia Perluigi
Journal:  Antioxid Redox Signal       Date:  2016-10-26       Impact factor: 8.401

Review 10.  Recent advances in the genetics of the ALS-FTLD complex.

Authors:  Huw R Morris; Adrian J Waite; Nigel M Williams; James W Neal; Derek J Blake
Journal:  Curr Neurol Neurosci Rep       Date:  2012-06       Impact factor: 5.081
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