AIMS: This study examined brain activity using functional magnetic resonance imaging (fMRI) and reaction time (RT) during an implicit repetition priming memory task involving alcohol, polydrug, marijuana and emotional picture cues. METHODS:Participants were 5 male and 5 female high-risk college students who had just participated in a cue exposure study (Ray et al., this issue). fMRI and RT data were collected while participants made decisions about previously seen and new picture cues. RESULTS: Both behavioral RT and brain imaging data revealed strong memory priming for drug and alcohol cues. Neurologically, a repetition priming effect (suppression in neural activity for repeated cues) was observed in response to alcohol cues in the left prefrontal, bilateral occipital, and bilateral occipitotemporal regions, as well as right insula and right precuneus (Z ranged from 3.03 to 3.31 P < 0.05). Polydrug cues elicited priming in the occipital and temporal areas, and marijuana cues in the occipital area. CONCLUSIONS: Prefrontal and insular cortex involvement both in reactivity to alcohol cues (Ray et al., this issue) and subsequent implicit memory processing of these cues, as found in this study, suggests their potential role in the maintenance of high-risk alcohol use behaviors.
RCT Entities:
AIMS: This study examined brain activity using functional magnetic resonance imaging (fMRI) and reaction time (RT) during an implicit repetition priming memory task involving alcohol, polydrug, marijuana and emotional picture cues. METHODS:Participants were 5 male and 5 female high-risk college students who had just participated in a cue exposure study (Ray et al., this issue). fMRI and RT data were collected while participants made decisions about previously seen and new picture cues. RESULTS: Both behavioral RT and brain imaging data revealed strong memory priming for drug and alcohol cues. Neurologically, a repetition priming effect (suppression in neural activity for repeated cues) was observed in response to alcohol cues in the left prefrontal, bilateral occipital, and bilateral occipitotemporal regions, as well as right insula and right precuneus (Z ranged from 3.03 to 3.31 P < 0.05). Polydrug cues elicited priming in the occipital and temporal areas, and marijuana cues in the occipital area. CONCLUSIONS: Prefrontal and insular cortex involvement both in reactivity to alcohol cues (Ray et al., this issue) and subsequent implicit memory processing of these cues, as found in this study, suggests their potential role in the maintenance of high-risk alcohol use behaviors.
Authors: Hugh Myrick; Raymond F Anton; Xingbao Li; Scott Henderson; David Drobes; Konstantin Voronin; Mark S George Journal: Neuropsychopharmacology Date: 2004-02 Impact factor: 7.853
Authors: Ingo G Meister; Jürgen Weidemann; Henrik Foltys; Henning Brand; Klaus Willmes; Timo Krings; Armin Thron; Rudolf Töpper; Babak Boroojerdi Journal: Eur J Neurosci Date: 2005-02 Impact factor: 3.386
Authors: Paul Bentley; Patrik Vuilleumier; Christiane M Thiel; Jon Driver; Raymond J Dolan Journal: J Neurophysiol Date: 2003-03-20 Impact factor: 2.714
Authors: Alecia D Dager; Beth M Anderson; Michael C Stevens; Carmen Pulido; Rivkah Rosen; Rachel E Jiantonio-Kelly; Jason-Flor Sisante; Sarah A Raskin; Howard Tennen; Carol S Austad; Rebecca M Wood; Carolyn R Fallahi; Godfrey D Pearlson Journal: Alcohol Clin Exp Res Date: 2012-10-18 Impact factor: 3.455