| Literature DB >> 20728357 |
Jin-Hun Park1, Jeong-Soo Chang, Mohammed I El-Gamal, Won-Kyoung Choi, Woong San Lee, Hye Jin Chung, Hyun-Il Kim, Young-Jin Cho, Bong Sang Lee, Hong-Ryeol Jeon, Yong Sup Lee, Young Wook Choi, Jaehwi Lee, Chang-Hyun Oh.
Abstract
Synthesis of novel amides and esters prodrugs of olmesartan is described. Their in vitro stability in rat plasma was tested. The results showed that the ester derivative IIa with n-octyl substituted dioxolone moiety was rapidly converted into olmesartan within 30 min. The pharmacokinetic parameters of IIa were studied and compared with those of olmesartan medoxomil. Compound IIa is proposed to be a promising prodrug of olmesartan.Entities:
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Year: 2010 PMID： 20728357 DOI： 10.1016/j.bmcl.2010.07.089
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823