First-principles modeling of fluid and solute exchange in the human during normal and hemodialysis conditions.

A first-principles computer model of fluid and solute exchange under both physiological and hemodialysis condition is presented. The whole system has been modeled and simulated under the MODELICA integrated environment, which uses a hierarchical modeling strategy. The model performance has been analyzed by simulation in the light of existing hypothesis and physiological data used here for validation purposes. The results obtained provide a physiological interpretative key to patient's hemodynamic behavior during hemodialysis.