Kirnpal-Kaur Banga Singh1,2, W A Wan-Nurfahizul-Izzati1, Asma Ismail1. 1. Institute for Research in Molecular Medicine (INFORMM), Universiti Sains Malaysia, Health Campus, 16150 Kubang Kerian, Kelantan, Malaysia. 2. Department of Medical Microbiology & Parasitology, School of Medical Sciences, Health Campus, Universiti Sains Malaysia, 16150 Kubang Kerian, Kelantan, Malaysia.
Abstract
BACKGROUND: Neopterin is produced by human macrophages/monocytes when stimulated with interferon-gamma. Production of neopterin is found in serum, cerebrospinal fluid (CSF) and urine of patients with infections by viruses, intracellular bacteria and parasites, autoimmune diseases, malignant tumors and patients in allograft rejection episodes. METHODS: In this study, the level of neopterin was determined in serum samples obtained from patients infected with Shigella (all four species) and healthy individuals. The study population comprised of 14 patients infected with Shigella and 14 normal controls. Serum neopterin was measured using an enzyme-linked immunosorbent assay (ELISA). RESULTS: The mean of serum neopterin concentration was 36.32 ± 9.71 nmol/L among patients infected with Shigella and 2.88 ± 0.77 nmol/L in the control group. The mean serum neopterin levels were significantly higher in the test group as compared to the normal group (p = 0.002). CONCLUSION: This study revealed that neopterin was elevated in patients infected with Shigella.
BACKGROUND:Neopterin is produced by human macrophages/monocytes when stimulated with interferon-gamma. Production of neopterin is found in serum, cerebrospinal fluid (CSF) and urine of patients with infections by viruses, intracellular bacteria and parasites, autoimmune diseases, malignant tumors and patients in allograft rejection episodes. METHODS: In this study, the level of neopterin was determined in serum samples obtained from patients infected with Shigella (all four species) and healthy individuals. The study population comprised of 14 patients infected with Shigella and 14 normal controls. Serum neopterin was measured using an enzyme-linked immunosorbent assay (ELISA). RESULTS: The mean of serum neopterin concentration was 36.32 ± 9.71 nmol/L among patients infected with Shigella and 2.88 ± 0.77 nmol/L in the control group. The mean serum neopterin levels were significantly higher in the test group as compared to the normal group (p = 0.002). CONCLUSION: This study revealed that neopterin was elevated in patients infected with Shigella.
Authors: Pablo Avanzas; Ramon Arroyo-Espliguero; Juan Quiles; Debashis Roy; Juan Carlos Kaski Journal: Eur Heart J Date: 2005-01-31 Impact factor: 29.983
Authors: D Fuchs; F Chiodi; J Albert; B Asjö; L Hagberg; A Hausen; G Norkrans; G Reibnegger; E R Werner; H Wachter Journal: AIDS Date: 1989-05 Impact factor: 4.177
Authors: K L Kotloff; J P Winickoff; B Ivanoff; J D Clemens; D L Swerdlow; P J Sansonetti; G K Adak; M M Levine Journal: Bull World Health Organ Date: 1999 Impact factor: 9.408