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Literature DB >> 20725108

NFAT, immunity and cancer: a transcription factor comes of age.

Abstract

Nuclear factor of activated T cells (NFAT) was first identified more than two decades ago as a major stimulation-responsive DNA-binding factor and transcriptional regulator in T cells. It is now clear that NFAT proteins have important functions in other cells of the immune system and regulate numerous developmental programmes in vertebrates. Dysregulation of these programmes can lead to malignant growth and cancer. This Review focuses on recent advances in our understanding of the transcriptional functions of NFAT proteins in the immune system and provides new insights into their potential roles in cancer development.

Entities: Disease

Mesh：

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Year: 2010 PMID： 20725108 DOI： 10.1038/nri2818

Source DB: PubMed Journal: Nat Rev Immunol ISSN： 1474-1733 Impact factor: 53.106

118 in total

1. Selective inhibition of calcineurin-NFAT signaling by blocking protein-protein interaction with small organic molecules.

Authors: Michael H A Roehrl; Sunghyun Kang; José Aramburu; Gerhard Wagner; Anjana Rao; Patrick G Hogan
Journal: Proc Natl Acad Sci U S A Date: 2004-05-06 Impact factor: 11.205

2. A genome-wide Drosophila RNAi screen identifies DYRK-family kinases as regulators of NFAT.

Authors: Yousang Gwack; Sonia Sharma; Julie Nardone; Bogdan Tanasa; Alina Iuga; Sonal Srikanth; Heidi Okamura; Diana Bolton; Stefan Feske; Patrick G Hogan; Anjana Rao
Journal: Nature Date: 2006-03-01 Impact factor: 49.962

Review 3. Transcriptional regulation by calcium, calcineurin, and NFAT.

Authors: Patrick G Hogan; Lin Chen; Julie Nardone; Anjana Rao
Journal: Genes Dev Date: 2003-09-15 Impact factor: 11.361

4. Hyperactivation of nuclear factor of activated T cells 1 (NFAT1) in T cells attenuates severity of murine autoimmune encephalomyelitis.

Authors: Srimoyee Ghosh; Sergei B Koralov; Irena Stevanovic; Mark S Sundrud; Yoshiteru Sasaki; Klaus Rajewsky; Anjana Rao; Martin R Müller
Journal: Proc Natl Acad Sci U S A Date: 2010-08-09 Impact factor: 11.205

5. A CD8 T cell-intrinsic role for the calcineurin-NFAT pathway for tolerance induction in vivo.

Authors: Thomas Fehr; Carrie L Lucas; Josef Kurtz; Takashi Onoe; Guiling Zhao; Timothy Hogan; Casey Vallot; Anjana Rao; Megan Sykes
Journal: Blood Date: 2009-12-10 Impact factor: 22.113

6. NFAT-induced histone acetylation relay switch promotes c-Myc-dependent growth in pancreatic cancer cells.

Authors: Alexander Köenig; Thomas Linhart; Katrin Schlengemann; Kristina Reutlinger; Jessica Wegele; Guido Adler; Garima Singh; Leonie Hofmann; Steffen Kunsch; Thomas Büch; Eva Schäfer; Thomas M Gress; Martin E Fernandez-Zapico; Volker Ellenrieder
Journal: Gastroenterology Date: 2009-11-06 Impact factor: 22.682

7. Dual activity lysophosphatidic acid receptor pan-antagonist/autotaxin inhibitor reduces breast cancer cell migration in vitro and causes tumor regression in vivo.

Authors: Honglu Zhang; Xiaoyu Xu; Joanna Gajewiak; Ryoko Tsukahara; Yuko Fujiwara; Jianxiong Liu; James I Fells; Donna Perygin; Abby L Parrill; Gabor Tigyi; Glenn D Prestwich
Journal: Cancer Res Date: 2009-06-09 Impact factor: 12.701

Review 8. Epigenetic control of FOXP3 expression: the key to a stable regulatory T-cell lineage?

Authors: Jochen Huehn; Julia K Polansky; Alf Hamann
Journal: Nat Rev Immunol Date: 2009-02 Impact factor: 53.106

9. HIF-1alpha is up-regulated in activated mast cells by a process that involves calcineurin and NFAT.

Authors: Aurelia Walczak-Drzewiecka; Marcin Ratajewski; Waldemar Wagner; Jaroslaw Dastych
Journal: J Immunol Date: 2008-08-01 Impact factor: 5.422

10. Prostaglandin F(2alpha)-F-prostanoid receptor regulates CXCL8 expression in endometrial adenocarcinoma cells via the calcium-calcineurin-NFAT pathway.

Authors: Kurt J Sales; David Maldonado-Pérez; Vivien Grant; Rob D Catalano; Martin R Wilson; Pamela Brown; Alistair R W Williams; Richard A Anderson; E Aubrey Thompson; Henry N Jabbour
Journal: Biochim Biophys Acta Date: 2009-10-09

248 in total

1. Restricted heterochromatin formation links NFATc2 repressor activity with growth promotion in pancreatic cancer.

Authors: Sandra Baumgart; Elisabeth Glesel; Garima Singh; Nai-Ming Chen; Kristina Reutlinger; Jinsan Zhang; Daniel D Billadeau; Martin E Fernandez-Zapico; Thomas M Gress; Shiv K Singh; Volker Ellenrieder
Journal: Gastroenterology Date: 2011-11-10 Impact factor: 22.682

2. Don't move: LRRK2 arrests NFAT in the cytoplasm.

Authors: Bana Jabri; Luis B Barreiro
Journal: Nat Immunol Date: 2011-10-19 Impact factor: 25.606

Review 3. Unraveling STIM2 function.

Authors: Esther López; Ginés M Salido; Juan A Rosado; Alejandro Berna-Erro
Journal: J Physiol Biochem Date: 2012-04-03 Impact factor: 4.158

4. Calcineurin/NFATc1 pathway contributes to cell proliferation in hepatocellular carcinoma.

Authors: Shuhuai Wang; Xinmei Kang; Shouqiang Cao; Hui Cheng; Di Wang; Jingshu Geng
Journal: Dig Dis Sci Date: 2012-06-22 Impact factor: 3.199

5. Curcumin suppresses T cell activation by blocking Ca2+ mobilization and nuclear factor of activated T cells (NFAT) activation.

Authors: Christian Kliem; Anette Merling; Marco Giaisi; Rebecca Köhler; Peter H Krammer; Min Li-Weber
Journal: J Biol Chem Date: 2012-02-02 Impact factor: 5.157

10. Endorepellin affects angiogenesis by antagonizing diverse vascular endothelial growth factor receptor 2 (VEGFR2)-evoked signaling pathways: transcriptional repression of hypoxia-inducible factor 1α and VEGFA and concurrent inhibition of nuclear factor of activated T cell 1 (NFAT1) activation.

Authors: Atul Goyal; Chiara Poluzzi; Chris D Willis; James Smythies; Adam Shellard; Thomas Neill; Renato V Iozzo
Journal: J Biol Chem Date: 2012-10-11 Impact factor: 5.157