BACKGROUND: The authors previously identified a significant association between lumbar disc degeneration (LDDG) and cartilage intermediate layer protein (CILP) single nucleotide polymorphism (SNP) in collegiate male judokas. HYPOTHESIS: A significant association between LDDG and the CILP SNP is observed in Japanese collegiate athletes. STUDY DESIGN: Cross-sectional study; Level of evidence, 3. METHODS: The participants were 601 trained collegiate athletes (male, 403; female, 198) from 7 different sports. Lumbar disc degeneration was evaluated using T2-weighted magnetic resonance imaging. Genotyping of the CILP gene (1184T/C) was performed by using DNA sequencing. RESULTS: Among the 601 collegiate athletes, the odds ratio (OR) for the occurrence of LDDG with the CILP C allele was 1.4 (95% confidence interval [CI], 1.05-1.86). By using logistic regression analysis concomitant with the interaction term and the Wald test, the authors found that weight (OR, 1.04; 95% CI, 1.02-1.06), CILP genotype (CT: OR, 2.0; 95% CI, 1.24-3.15; CC: OR, 2.9; 95% CI, 1.09-7.74), and gender (OR, 2.1; 95% CI, 1.21-3.67) were significant risk factors for LDDG. These analyses also indicated that there was no effect of the CILP genotype on LDDG in female athletes. CONCLUSION: The CILP SNP 1184T/C is a risk factor for male collegiate athletes. Information regarding the CILP gene polymorphism may be important for preventing and managing lumbar disc diseases, especially in male athletes.
BACKGROUND: The authors previously identified a significant association between lumbar disc degeneration (LDDG) and cartilage intermediate layer protein (CILP) single nucleotide polymorphism (SNP) in collegiate male judokas. HYPOTHESIS: A significant association between LDDG and the CILP SNP is observed in Japanese collegiate athletes. STUDY DESIGN: Cross-sectional study; Level of evidence, 3. METHODS: The participants were 601 trained collegiate athletes (male, 403; female, 198) from 7 different sports. Lumbar disc degeneration was evaluated using T2-weighted magnetic resonance imaging. Genotyping of the CILP gene (1184T/C) was performed by using DNA sequencing. RESULTS: Among the 601 collegiate athletes, the odds ratio (OR) for the occurrence of LDDG with the CILP C allele was 1.4 (95% confidence interval [CI], 1.05-1.86). By using logistic regression analysis concomitant with the interaction term and the Wald test, the authors found that weight (OR, 1.04; 95% CI, 1.02-1.06), CILP genotype (CT: OR, 2.0; 95% CI, 1.24-3.15; CC: OR, 2.9; 95% CI, 1.09-7.74), and gender (OR, 2.1; 95% CI, 1.21-3.67) were significant risk factors for LDDG. These analyses also indicated that there was no effect of the CILP genotype on LDDG in female athletes. CONCLUSION: The CILP SNP 1184T/C is a risk factor for male collegiate athletes. Information regarding the CILP gene polymorphism may be important for preventing and managing lumbar disc diseases, especially in male athletes.
Authors: Paola Bermudez-Lekerika; Katherine B Crump; Sofia Tseranidou; Andrea Nüesch; Exarchos Kanelis; Ahmad Alminnawi; Laura Baumgartner; Estefano Muñoz-Moya; Roger Compte; Francesco Gualdi; Leonidas G Alexopoulos; Liesbet Geris; Karin Wuertz-Kozak; Christine L Le Maitre; Jérôme Noailly; Benjamin Gantenbein Journal: Front Cell Dev Biol Date: 2022-06-29
Authors: Jillian E Mayer; James C Iatridis; Danny Chan; Sheeraz A Qureshi; Omri Gottesman; Andrew C Hecht Journal: Spine J Date: 2013-03 Impact factor: 4.166
Authors: Anthi Kelempisioti; Pasi J Eskola; Annaleena Okuloff; Ulla Karjalainen; Jani Takatalo; Iita Daavittila; Jaakko Niinimäki; Roberto B Sequeiros; Osmo Tervonen; Svetlana Solovieva; Patrick Y P Kao; You-Qiang Song; Kenneth M C Cheung; Danny Chan; Leena Ala-Kokko; Marjo-Riitta Järvelin; Jaro Karppinen; Minna Männikkö Journal: BMC Med Genet Date: 2011-11-22 Impact factor: 2.103
Authors: Pasi J Eskola; Susanna Lemmelä; Per Kjaer; Svetlana Solovieva; Minna Männikkö; Niels Tommerup; Allan Lind-Thomsen; Kirsti Husgafvel-Pursiainen; Kenneth M C Cheung; Danny Chan; Dino Samartzis; Jaro Karppinen Journal: PLoS One Date: 2012-11-21 Impact factor: 3.240