Nathan L Salinas1, Jose E Barrera. 1. Department of Otolaryngology, Brooke Army Medical Center, Fort Sam Houston, TX, USA. nathan.salinas@us.army.mil
Abstract
OBJECTIVE: To investigate, in a porcine tongue model, the lesions created by coblation to define the optimal application of this method in treating the enlarged tongue base in patients with obstructive sleep apnea syndrome. STUDY DESIGN: A prospective, experimental animal study. SETTING: Military medical center. SUBJECTS AND METHODS: Fifteen fresh porcine tongue specimens were injected with normal saline, and a single coblation probe was applied to the tongue specimens to create multiple submucosal lesions at specific energy settings. Control lesions were created without the use of saline injections. After creating the lesions, the porcine tongue specimens were sectioned and examined grossly. Size and character of lesions were recorded for each of the specimens and were compared across energy settings. RESULTS: The energy applied at each setting was calculated on the basis of watts multiplied by treatment time. Coblation with saline injection created visible lesions with an average lesion area of 1.20 to 2.87 cm(2). The average lesion area increased as setting increased. Without saline injection, the average lesion area was 0.15 to 0.8 cm(2). CONCLUSION: The porcine tongue model describes the relationship between lesion size and cold ablation device settings. Setting, but not time, significantly affects lesion size. The coblation setting and treatment time directly impact the amount of energy delivered. Additionally, submucosal normal saline injection significantly increases lesion size at all settings and application times. Given the average lesion diameter described in this study, placing lesions 1 cm apart will optimize the area affected by coblation while minimizing lesion overlap. Copyright 2010 American Academy of Otolaryngology-Head and Neck Surgery Foundation. Published by Mosby, Inc. All rights reserved.
OBJECTIVE: To investigate, in a porcine tongue model, the lesions created by coblation to define the optimal application of this method in treating the enlarged tongue base in patients with obstructive sleep apnea syndrome. STUDY DESIGN: A prospective, experimental animal study. SETTING: Military medical center. SUBJECTS AND METHODS: Fifteen fresh porcine tongue specimens were injected with normal saline, and a single coblation probe was applied to the tongue specimens to create multiple submucosal lesions at specific energy settings. Control lesions were created without the use of saline injections. After creating the lesions, the porcine tongue specimens were sectioned and examined grossly. Size and character of lesions were recorded for each of the specimens and were compared across energy settings. RESULTS: The energy applied at each setting was calculated on the basis of watts multiplied by treatment time. Coblation with saline injection created visible lesions with an average lesion area of 1.20 to 2.87 cm(2). The average lesion area increased as setting increased. Without saline injection, the average lesion area was 0.15 to 0.8 cm(2). CONCLUSION: The porcine tongue model describes the relationship between lesion size and cold ablation device settings. Setting, but not time, significantly affects lesion size. The coblation setting and treatment time directly impact the amount of energy delivered. Additionally, submucosal normal saline injection significantly increases lesion size at all settings and application times. Given the average lesion diameter described in this study, placing lesions 1 cm apart will optimize the area affected by coblation while minimizing lesion overlap. Copyright 2010 American Academy of Otolaryngology-Head and Neck Surgery Foundation. Published by Mosby, Inc. All rights reserved.
Authors: Stuart G MacKay; A Simon Carney; Charmaine Woods; Nick Antic; R Doug McEvoy; Michael Chia; Terry Sands; Andrew Jones; Jonathan Hobson; Samuel Robinson Journal: J Clin Sleep Med Date: 2013-02-01 Impact factor: 4.062
Authors: Kate Sutherland; Aimee B Lowth; Nick Antic; A Simon Carney; Peter G Catcheside; Ching Li Chai-Coetzer; Michael Chia; John-Charles Hodge; Andrew Jones; Billingsley Kaambwa; Richard Lewis; Stuart MacKay; R Doug McEvoy; Eng H Ooi; Alison J Pinczel; Nigel McArdle; Guy Rees; Bhajan Singh; Nicholas Stow; Edward M Weaver; Richard J Woodman; Charmaine M Woods; Aeneas Yeo; Peter A Cistulli Journal: Sleep Date: 2021-12-10 Impact factor: 6.313