Literature DB >> 20723750

Reversing cachexia.

Michael J Tisdale1.   

Abstract

Muscle atrophy (cachexia) in cancer patients is a life-threatening condition for which therapeutic options are limited. Zhou et al. (2010) now identify a new target for treating cachexia, the activin type-2 receptor (ActRIIB). In several mouse models of cachexia, the authors reversed wasting of skeletal and cardiac muscle and increased life span by blocking ActRIIB with a decoy receptor. Copyright 2010 Elsevier Inc. All rights reserved.

Entities:  

Year:  2010        PMID： 20723750     DOI： 10.1016/j.cell.2010.08.004

Source DB:  PubMed          Journal:  Cell        ISSN： 0092-8674            Impact factor:   41.582


  28 in total

1.  Quercetin supplementation attenuates the progression of cancer cachexia in ApcMin/+ mice.

Authors:  Kandy T Velázquez; Reilly T Enos; Aditi A Narsale; Melissa J Puppa; J Mark Davis; E Angela Murphy; James A Carson
Journal:  J Nutr       Date:  2014-04-23       Impact factor: 4.798

2.  Specific targeting of TGF-β family ligands demonstrates distinct roles in the regulation of muscle mass in health and disease.

Authors:  Justin L Chen; Kelly L Walton; Adam Hagg; Timothy D Colgan; Katharine Johnson; Hongwei Qian; Paul Gregorevic; Craig A Harrison
Journal:  Proc Natl Acad Sci U S A       Date:  2017-06-12       Impact factor: 11.205

3.  Inhibition of Stat3 activation suppresses caspase-3 and the ubiquitin-proteasome system, leading to preservation of muscle mass in cancer cachexia.

Authors:  Kleiton Augusto Santos Silva; Jiangling Dong; Yanjun Dong; Yanlan Dong; Nestor Schor; David J Tweardy; Liping Zhang; William E Mitch
Journal:  J Biol Chem       Date:  2015-03-18       Impact factor: 5.157

4.  Nutritional interventions for cancer-induced cachexia.

Authors:  Norleena P Gullett; Vera C Mazurak; Gautam Hebbar; Thomas R Ziegler
Journal:  Curr Probl Cancer       Date:  2011 Mar-Apr       Impact factor: 3.187

5.  Virtual High-Throughput Screening To Identify Novel Activin Antagonists.

Authors:  Jie Zhu; Rama K Mishra; Gary E Schiltz; Yogeshwar Makanji; Karl A Scheidt; Andrew P Mazar; Teresa K Woodruff
Journal:  J Med Chem       Date:  2015-07-07       Impact factor: 7.446

Review 6.  Cachexia in patients with oesophageal cancer.

Authors:  Poorna Anandavadivelan; Pernilla Lagergren
Journal:  Nat Rev Clin Oncol       Date:  2015-11-17       Impact factor: 66.675

7.  Nutritional Risk Index predicts mortality in hospitalized advanced heart failure patients.

Authors:  Oluwayemisi L Adejumo; Todd M Koelling; Scott L Hummel
Journal:  J Heart Lung Transplant       Date:  2015-06-11       Impact factor: 10.247

Review 8.  Molecular Pathways: Cachexia Signaling-A Targeted Approach to Cancer Treatment.

Authors:  Yuji Miyamoto; Diana L Hanna; Wu Zhang; Hideo Baba; Heinz-Josef Lenz
Journal:  Clin Cancer Res       Date:  2016-06-23       Impact factor: 12.531

Review 9.  Cachexia and pancreatic cancer: are there treatment options?

Authors:  Tara C Mueller; Marc A Burmeister; Jeannine Bachmann; Marc E Martignoni
Journal:  World J Gastroenterol       Date:  2014-07-28       Impact factor: 5.742

10.  Twist1 Activation in Muscle Progenitor Cells Causes Muscle Loss Akin to Cancer Cachexia.

Authors:  Parash Parajuli; Santosh Kumar; Audrey Loumaye; Purba Singh; Sailaja Eragamreddy; Thien Ly Nguyen; Seval Ozkan; Mohammed S Razzaque; Céline Prunier; Jean-Paul Thissen; Azeddine Atfi
Journal:  Dev Cell       Date:  2018-06-18       Impact factor: 12.270
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