Attenuation of anxiety in ambulatory oral surgery patients with oral triazolam.

The purpose of this investigation was to determine if the preoperative administration of an oral anxiolytic agent (triazolam) is beneficial in reducing the cardiovascular response to stress and anxiety. Twelve consecutive patients, six who received the drug and six who received a placebo, were monitored from the night before surgery at home until the morning with a Holter monitor. On presentation for surgery, levels of anxiety as well as heart rate and presence of cardiac arrhythmias were determined for the two groups. Patients who received the study medication had an anxiety level on the day of surgery similar to that recorded at an earlier consultation visit, whereas the placebo group showed a tendency toward an increase in anxiety on the day of surgery. There was a significant difference for resting heart rate between the two groups at various intervals associated with the preparation for the surgery. There were no complications related to the medication and, therefore, on the basis of this study, it appears that the administration of an oral anxiolytic agent prior to the patient presenting for surgery is beneficial in reducing the stress and anxiety associated with the operation as well as in reducing some of the cardiac manifestations of this stress.

RCT Entities:   Population Interventions Outcomes