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Literature DB >> 20720306

Chromosomal assignment of R-spondin genes in the donkey (Equus asinus, 2n = 62).

L De Lorenzi¹, V Genualdo, A Perucatti, G Pia Di Meo, L Molteni, L Iannuzzi, P Parma.

Abstract

R-spondins constitute a recently discovered small family of growth factors, and the evidence of their role in several developmental pathways is growing fast. In this work we describe the chromosomal location of the four RSPO genes in the donkey. Using horse BACs, we localized RSPO1 on EAS 5q23, RSPO2 on EAS 12q13, RSPO3 on EAS 24q26, and RSPO4 on EAS 15p13. Moreover, RSPO2, RSPO3, and RSPO4 are the first genes mapped on donkey chromosomes 12, 24, and 15, respectively.

Entities: Gene Species

Mesh：

Substances：
Thrombospondins

Year: 2010 PMID： 20720306 DOI： 10.1007/BF03208861

Source DB: PubMed Journal: J Appl Genet ISSN： 1234-1983 Impact factor: 3.240

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References

14 in total

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Chromosomal assignment of R-spondin genes in the donkey (Equus asinus, 2n = 62).

1. Activation of beta-catenin signaling by Rspo1 controls differentiation of the mammalian ovary.

2. Tools of the trade: diagnostics and research in domestic animal cytogenetics.

3. Chromosomal assignment of equine genes involved in the development of skeletal, gastrointestinal, cardiovascular and nervous system.

4. The gene encoding R-spondin 4 (RSPO4), a secreted protein implicated in Wnt signaling, is mutated in inherited anonychia.

5. R-spondin3 is required for mouse placental development.

6. R-Spondin proteins: a novel link to beta-catenin activation.

7. Comparative FISH mapping of 32 loci reveals new homologous regions between donkey and horse karyotypes.

8. The 450-band resolution G- and R-banded standard karyotype of the donkey (Equus asinus, 2n = 62).

9. Fluorescent in situ hybridization mapping of the epidermal growth factor receptor gene in donkey.

10. R-spondin1 is essential in sex determination, skin differentiation and malignancy.