PURPOSE: To further characterize the anatomy and sexual function of women with CAIS compared to normal females, and assess the utility of magnetic resonance imaging (MRI) to distinguish anatomical differences. MATERIALS AND METHODS: In a prospective cohort pilot study, five individuals with androgen insensitivity syndrome and six, normal, nulliparous women underwent an interview, physical examination, questionnaire completion and MRI of the pelvis. Statistical analysis was performed with emphasis on determining significant differences in anatomical findings and sexual satisfaction. RESULTS: MRI demonstrated statistically significant differences in vaginal depth and size that were not confirmed on physical exam. MRI and physical exam demonstrated a non-significant difference in average phallic thickness between the two groups, although the CAIS group clitoral width tended to be smaller. Physical exam demonstrated a higher average erect height and longer arm span in the CAIS patients but this was not statistically significant. No significant differences were noted in categories designed to assess satisfaction with ability to achieve orgasm, vaginal appearance and frequency of sexual intercourse between the two groups. CONCLUSIONS: The women with CAIS were as satisfied with sexual function as were the women within the control group. Physical exam and MRI did not find any statistically significant clinically relevant differences between the two groups.
PURPOSE: To further characterize the anatomy and sexual function of women with CAIS compared to normal females, and assess the utility of magnetic resonance imaging (MRI) to distinguish anatomical differences. MATERIALS AND METHODS: In a prospective cohort pilot study, five individuals with androgen insensitivity syndrome and six, normal, nulliparous women underwent an interview, physical examination, questionnaire completion and MRI of the pelvis. Statistical analysis was performed with emphasis on determining significant differences in anatomical findings and sexual satisfaction. RESULTS: MRI demonstrated statistically significant differences in vaginal depth and size that were not confirmed on physical exam. MRI and physical exam demonstrated a non-significant difference in average phallic thickness between the two groups, although the CAIS group clitoral width tended to be smaller. Physical exam demonstrated a higher average erect height and longer arm span in the CAIS patients but this was not statistically significant. No significant differences were noted in categories designed to assess satisfaction with ability to achieve orgasm, vaginal appearance and frequency of sexual intercourse between the two groups. CONCLUSIONS: The women with CAIS were as satisfied with sexual function as were the women within the control group. Physical exam and MRI did not find any statistically significant clinically relevant differences between the two groups.
Authors: Laurence Baskin; Joel Shen; Adriane Sinclair; Mei Cao; Xin Liu; Ge Liu; Dylan Isaacson; Maya Overland; Yi Li; Gerald R Cunha Journal: Differentiation Date: 2018-08-23 Impact factor: 3.880
Authors: Laurence Baskin; Adriane Sinclair; Amber Derpinghaus; Mei Cao; Yi Li; Maya Overland; Sena Aksel; Gerald R Cunha Journal: Differentiation Date: 2020-10-01 Impact factor: 3.880