Warning: Undefined array key "mm" in /www/wwwroot/www.ai-bt.com/si.php on line 10 Deprecated: trim(): Passing null to parameter #1 ($string) of type string is deprecated in /www/wwwroot/www.ai-bt.com/si.php on line 10 Small-molecule modulators of zymogen activation in the fibrinolytic and coagulation systems.

Literature DB >> 20718867

Small-molecule modulators of zymogen activation in the fibrinolytic and coagulation systems.

Keiji Hasumi¹, Shingo Yamamichi, Tomotaka Harada.

Abstract

The coagulation and fibrinolytic systems are central to the hemostatic mechanism, which works promptly on vascular injury and tissue damage. The rapid response is generated by specific molecular interactions between components in these systems. Thus, the regulation mechanism of the systems is programmed in each component, as exemplified by the elegant processes in zymogen activation. This review describes recently identified small molecules that modulate the activation of zymogens in the fibrinolytic and coagulation systems.

Entities: Disease

Mesh：

Substances：

Year: 2010 PMID： 20718867 DOI： 10.1111/j.1742-4658.2010.07783.x

Source DB: PubMed Journal: FEBS J ISSN： 1742-464X Impact factor: 5.542

Keyword Cloud
Cited

16 in total

1. Soluble epoxide hydrolase as an anti-inflammatory target of the thrombolytic stroke drug SMTP-7.

Authors: Naoki Matsumoto; Eriko Suzuki; Makoto Ishikawa; Takumi Shirafuji; Keiji Hasumi
Journal: J Biol Chem Date: 2014-10-31 Impact factor: 5.157

2. Structure-activity relationships of the plasminogen modulator SMTP with respect to the inhibition of soluble epoxide hydrolase.

Authors: Naoki Matsumoto; Eriko Suzuki; Kota Tsujihara; Yuuichi Nishimura; Keiji Hasumi
Journal: J Antibiot (Tokyo) Date: 2015-05-13 Impact factor: 2.649

Review 3. Progress in Isoindolone Alkaloid Derivatives from Marine Microorganism: Pharmacology, Preparation, and Mechanism.

Authors: Sijin Hang; Hui Chen; Wenhui Wu; Shiyi Wang; Yiwen Fang; Ruilong Sheng; Qidong Tu; Ruihua Guo
Journal: Mar Drugs Date: 2022-06-20 Impact factor: 6.085

10. Producing Novel Fibrinolytic Isoindolinone Derivatives in Marine Fungus Stachybotrys longispora FG216 by the Rational Supply of Amino Compounds According to Its Biosynthesis Pathway.

Authors: Ying Yin; Qiang Fu; Wenhui Wu; Menghao Cai; Xiangshan Zhou; Yuanxing Zhang
Journal: Mar Drugs Date: 2017-07-05 Impact factor: 5.118

Small-molecule modulators of zymogen activation in the fibrinolytic and coagulation systems.

1. Soluble epoxide hydrolase as an anti-inflammatory target of the thrombolytic stroke drug SMTP-7.

2. Structure-activity relationships of the plasminogen modulator SMTP with respect to the inhibition of soluble epoxide hydrolase.

Review 3. Progress in Isoindolone Alkaloid Derivatives from Marine Microorganism: Pharmacology, Preparation, and Mechanism.

Review 4. New insights into the role of Plg-RKT in macrophage recruitment.

Review 5. Plasminogen receptors: the first quarter century.

6. SMTP-7, a novel small-molecule thrombolytic for ischemic stroke: a study in rodents and primates.

7. SMTP (Stachybotrys microspora triprenyl phenol) enhances clot clearance in a pulmonary embolism model in rats.

8. Efficacy of SMTP-7, a small-molecule anti-inflammatory thrombolytic, in embolic stroke in monkeys.

Review 9. Small Molecules: Therapeutic Application in Neuropsychiatric and Neurodegenerative Disorders.

10. Producing Novel Fibrinolytic Isoindolinone Derivatives in Marine Fungus Stachybotrys longispora FG216 by the Rational Supply of Amino Compounds According to Its Biosynthesis Pathway.