Literature DB >> 20718801

Surveillance of autopsy cases for D222G substitutions in haemagglutinin of the pandemic (H1N1) 2009 virus in Alberta, Canada.

S J Drews1, K Pabbaraju, S Wong, K L Tokaryk, J May-Hadford, B Lee, R Tellier, M Louie.   

Abstract

Pandemic (H1N1) 2009 virus-positive specimens were collected from autopsy patients and matched to pandemic (H1N1) 2009 virus-positive nasopharyngeal specimens from community control patients and pandemic (H1N1) 2009 virus-positive specimens from intensive-care unit (ICU) patients. Specimens were analysed for polymorphisms at amino acid 222 of the haemagglutinin (HA) glycoprotein. Whereas some specimens from autopsy patients were positive for D222N, none was positive for D222G. All control patient specimens were wild-type D222. D222G polymorphisms were also identified in a subset of ICU patients with admixtures of D222G and D222 and of D222N, D222G and D222 present. The relevance of D222N and D222G to influenza pathogenesis and transmissibility currently remains unclear.
© 2010 The Authors. Clinical Microbiology and Infection © 2010 European Society of Clinical Microbiology and Infectious Diseases.

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Year:  2010        PMID： 20718801     DOI： 10.1111/j.1469-0691.2010.03341.x

Source DB:  PubMed          Journal:  Clin Microbiol Infect        ISSN： 1198-743X            Impact factor:   8.067


  5 in total

Review 1.  Two years after pandemic influenza A/2009/H1N1: what have we learned?

Authors:  Vincent C C Cheng; Kelvin K W To; Herman Tse; Ivan F N Hung; Kwok-Yung Yuen
Journal:  Clin Microbiol Rev       Date:  2012-04       Impact factor: 26.132

2.  In vivo evaluation of pathogenicity and transmissibility of influenza A(H1N1)pdm09 hemagglutinin receptor binding domain 222 intrahost variants isolated from a single immunocompromised patient.

Authors:  Matthew J Memoli; Tyler Bristol; Kathleen E Proudfoot; A Sally Davis; Eleca J Dunham; Jeffery K Taubenberger
Journal:  Virology       Date:  2012-06-20       Impact factor: 3.616

3.  Direct association between pharyngeal viral secretion and host cytokine response in severe pandemic influenza.

Authors:  Raquel Almansa; Andres Anton; Paula Ramirez; Ignacio Martin-Loeches; David Banner; Tomás Pumarola; Luoling Xu; Jesús Blanco; Longsi Ran; Guillermo Lopez-Campos; Fernando Martin-Sanchez; Lorenzo Socias; Ana Loza; David Andaluz; Enrique Maravi; Mónica Gordón; Maria C Gallegos; Victoria Fernandez; Cristobal León; Pedro Merino; Maria Angeles Marcos; Francisco Gandía; Felipe Bobillo; Salvador Resino; Jose M Eiros; Carmen Castro; Paula Mateo; Milagros Gonzalez-Rivera; Jordi Rello; Raul Ortiz de Lejarazu; David J Kelvin; Jesus F Bermejo-Martin
Journal:  BMC Infect Dis       Date:  2011-08-31       Impact factor: 3.090

4.  A perspective on multiple waves of influenza pandemics.

Authors:  Anna Mummert; Howard Weiss; Li-Ping Long; José M Amigó; Xiu-Feng Wan
Journal:  PLoS One       Date:  2013-04-23       Impact factor: 3.240

5.  A(H1N1)pdm09 hemagglutinin D222G and D222N variants are frequently harbored by patients requiring extracorporeal membrane oxygenation and advanced respiratory assistance for severe A(H1N1)pdm09 infection.

Authors:  Tina Ruggiero; Francesco De Rosa; Francesco Cerutti; Nicole Pagani; Tiziano Allice; Maria L Stella; Maria G Milia; Andrea Calcagno; Elisa Burdino; Gabriella Gregori; Rosario Urbino; Giovanni Di Perri; Marco V Ranieri; Valeria Ghisetti
Journal:  Influenza Other Respir Viruses       Date:  2013-08-09       Impact factor: 4.380
  5 in total

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