| Literature DB >> 2071489 |
M Aoki1, H Shirai, N Nakayama, Y Itezono, M Mori, T Satoh, S Ohshima, J Watanabe, K Yokose, H Seto.
Abstract
Avidinorubicin (MW 1,214, C60H86N4O22) was isolated from the cultured broth of strain NR0576 (which was identified as Streptomyces avidinii Stapley et al.) by butyl alcohol extraction, Sephadex LH-20 column chromatography and preparative HPLC. Avidinorubicin inhibited thrombin-induced platelet aggregation with an IC50 being 7.9 microM and was determined to be a novel anthracycline possessing two units of a new aminosugar, avidinosamine, in place of two decilonitrose groups in decilorubicin.Entities:
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Year: 1991 PMID： 2071489 DOI： 10.7164/antibiotics.44.635
Source DB: PubMed Journal: J Antibiot (Tokyo) ISSN： 0021-8820 Impact factor: 2.649