Literature DB >> 2071486

Cyclothiazomycin, a novel polythiazole-containing peptide with renin inhibitory activity. Taxonomy, fermentation, isolation and physico-chemical characterization.

M Aoki1, T Ohtsuka, M Yamada, Y Ohba, H Yoshizaki, H Yasuno, T Sano, J Watanabe, K Yokose, H Seto.   

Abstract

Cyclothiazomycin is a novel renin inhibitor produced by Streptomyces sp. NR0516. It was isolated from fermentation broth by extraction with butyl alcohol, QAE-Toyopearl column chromatography and preparative HPLC. Cyclothiazomycin, which was determined to be a unique polythiazole-containing bicyclic peptide, exhibited inhibitory activity against human plasma renin with IC50 being 1.7 microM.

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Year:  1991        PMID： 2071486     DOI： 10.7164/antibiotics.44.582

Source DB:  PubMed          Journal:  J Antibiot (Tokyo)        ISSN： 0021-8820            Impact factor:   2.649


  8 in total

Review 1.  Thiazolyl peptide antibiotic biosynthesis: a cascade of post-translational modifications on ribosomal nascent proteins.

Authors:  Christopher T Walsh; Michael G Acker; Albert A Bowers
Journal:  J Biol Chem       Date:  2010-06-03       Impact factor: 5.157

Review 2.  Antifungal peptides produced by actinomycetes and their biological activities against plant diseases.

Authors:  Dong Zhang; Yuele Lu; Hanchi Chen; Chutian Wu; Hui Zhang; Luyi Chen; Xiaolong Chen
Journal:  J Antibiot (Tokyo)       Date:  2020-03-02       Impact factor: 2.649

3.  Identification and analysis of the biosynthetic gene cluster encoding the thiopeptide antibiotic cyclothiazomycin in Streptomyces hygroscopicus 10-22.

Authors:  Jiang Wang; Yi Yu; Kexuan Tang; Wen Liu; Xinyi He; Xi Huang; Zixin Deng
Journal:  Appl Environ Microbiol       Date:  2010-02-12       Impact factor: 4.792

Review 4.  YcaO-Dependent Posttranslational Amide Activation: Biosynthesis, Structure, and Function.

Authors:  Brandon J Burkhart; Christopher J Schwalen; Greg Mann; James H Naismith; Douglas A Mitchell
Journal:  Chem Rev       Date:  2017-03-03       Impact factor: 60.622

Review 5.  Ribosomally synthesized and post-translationally modified peptide natural products: overview and recommendations for a universal nomenclature.

Authors:  Paul G Arnison; Mervyn J Bibb; Gabriele Bierbaum; Albert A Bowers; Tim S Bugni; Grzegorz Bulaj; Julio A Camarero; Dominic J Campopiano; Gregory L Challis; Jon Clardy; Paul D Cotter; David J Craik; Michael Dawson; Elke Dittmann; Stefano Donadio; Pieter C Dorrestein; Karl-Dieter Entian; Michael A Fischbach; John S Garavelli; Ulf Göransson; Christian W Gruber; Daniel H Haft; Thomas K Hemscheidt; Christian Hertweck; Colin Hill; Alexander R Horswill; Marcel Jaspars; Wendy L Kelly; Judith P Klinman; Oscar P Kuipers; A James Link; Wen Liu; Mohamed A Marahiel; Douglas A Mitchell; Gert N Moll; Bradley S Moore; Rolf Müller; Satish K Nair; Ingolf F Nes; Gillian E Norris; Baldomero M Olivera; Hiroyasu Onaka; Mark L Patchett; Joern Piel; Martin J T Reaney; Sylvie Rebuffat; R Paul Ross; Hans-Georg Sahl; Eric W Schmidt; Michael E Selsted; Konstantin Severinov; Ben Shen; Kaarina Sivonen; Leif Smith; Torsten Stein; Roderich D Süssmuth; John R Tagg; Gong-Li Tang; Andrew W Truman; John C Vederas; Christopher T Walsh; Jonathan D Walton; Silke C Wenzel; Joanne M Willey; Wilfred A van der Donk
Journal:  Nat Prod Rep       Date:  2013-01       Impact factor: 13.423

Review 6.  Thiopeptide antibiotics: retrospective and recent advances.

Authors:  Xavier Just-Baringo; Fernando Albericio; Mercedes Álvarez
Journal:  Mar Drugs       Date:  2014-01-17       Impact factor: 5.118

Review 7.  α,β-Dehydroamino acids in naturally occurring peptides.

Authors:  Dawid Siodłak
Journal:  Amino Acids       Date:  2014-10-17       Impact factor: 3.520

8.  Nucleophilic 1,4-additions for natural product discovery.

Authors:  Courtney L Cox; Jonathan I Tietz; Karol Sokolowski; Joel O Melby; James R Doroghazi; Douglas A Mitchell
Journal:  ACS Chem Biol       Date:  2014-06-17       Impact factor: 5.100
  8 in total

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