Literature DB >> 20714816

[Biosurgical débridement using Lucilia sericata-maggots - an update].

Pietro Nenoff1, Antonia Herrmann, Christina Gerlach, Jürgen Herrmann, Jan Christoph Simon.   

Abstract

During the last years an increasing number of patients suffering from therapy refractory chronic wounds which are frequently infected by multi-resistant bacteria - e.g. methicillin-resistant Staphylococcus aureus - have led to an increasing interest in the treatment using larvae or maggots of the blow fly species Lucilia sericata. Maggots are responsible for necrectomy and they have antimicrobial activity in particular against grampositive bacteria like a disinfectant of the wound. It is concluded that maggots debridement therapy (MDT) using larvae of the species Lucilia sericata in non-healing chronic ulcers of the lower legs successfully leads to cleaning, debridement, reduced bacterial load, and improved wound granulation. A review is given on the clinical use of maggots, their mechanism of action and clinical efficacy for wound healing.

Entities:  

Mesh:

Year:  2010        PMID: 20714816     DOI: 10.1007/s10354-010-0806-1

Source DB:  PubMed          Journal:  Wien Med Wochenschr        ISSN: 0043-5341


  35 in total

Review 1.  An overview of maggot therapy used on chronic wounds in the community.

Authors:  Mary Jones
Journal:  Br J Community Nurs       Date:  2009-03

Review 2.  Debridement of diabetic foot ulcers.

Authors:  Jude Edwards; Sally Stapley
Journal:  Cochrane Database Syst Rev       Date:  2010-01-20

Review 3.  Maggot therapy takes us back to the future of wound care: new and improved maggot therapy for the 21st century.

Authors:  Ronald A Sherman
Journal:  J Diabetes Sci Technol       Date:  2009-03-01

4.  Multiple bacterial species reside in chronic wounds: a longitudinal study.

Authors:  Kristine Gjødsbøl; Jens Jørgen Christensen; Tonny Karlsmark; Bo Jørgensen; Bjarke M Klein; Karen A Krogfelt
Journal:  Int Wound J       Date:  2006-09       Impact factor: 3.315

5.  In vitro antibacterial activity of Lucilia sericata maggot secretions.

Authors:  G Daeschlein; K Y Mumcuoglu; O Assadian; B Hoffmeister; A Kramer
Journal:  Skin Pharmacol Physiol       Date:  2006-12-13       Impact factor: 3.479

6.  Septic injury-inducible genes in medicinal maggots of the green blow fly Lucilia sericata.

Authors:  B Altincicek; A Vilcinskas
Journal:  Insect Mol Biol       Date:  2008-12-08       Impact factor: 3.585

7.  Changes in quality of life for patients with chronic venous insufficiency, present or healed leg ulcers.

Authors:  Regina Renner; Carl Gebhardt; Jan C Simon; Kurt Seikowski
Journal:  J Dtsch Dermatol Ges       Date:  2009-11       Impact factor: 5.584

8.  Maggot debridement therapy: a case study.

Authors:  Laura Jean van Veen
Journal:  J Wound Ostomy Continence Nurs       Date:  2008 Jul-Aug       Impact factor: 1.741

9.  Amino acid derivatives from Lucilia sericata excretions/secretions may contribute to the beneficial effects of maggot therapy via increased angiogenesis.

Authors:  A Bexfield; A E Bond; C Morgan; J Wagstaff; R P Newton; N A Ratcliffe; E Dudley; Y Nigam
Journal:  Br J Dermatol       Date:  2009-10-03       Impact factor: 9.302

10.  Quorum-sensing-regulated virulence factors in Pseudomonas aeruginosa are toxic to Lucilia sericata maggots.

Authors:  A S Andersen; B Joergensen; T Bjarnsholt; H Johansen; T Karlsmark; M Givskov; K A Krogfelt
Journal:  Microbiology (Reading)       Date:  2009-11-05       Impact factor: 2.777

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