| Literature DB >> 20714562 |
Karina C Gornall1, Siritron Samosorn, Bongkot Tanwirat, Apichart Suksamrarn, John B Bremner, Michael J Kelso, Jennifer L Beck.
Abstract
ESI mass spectrometry was used to assess the binding of 13-substituted, 5-nitro-2-phenylindolyl- and 2-naphthalenyl-based berberine derivatives to inter- and intramolecular G-quadruplex DNA molecules. In contrast with the parent berberine, the compounds showed selectivity for quadruplex over duplex DNA and stabilised the quadruplex structure. They represent a new class of quadruplex DNA-selective ligands.Entities:
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Year: 2010 PMID： 20714562 DOI： 10.1039/c0cc01933j
Source DB: PubMed Journal: Chem Commun (Camb) ISSN： 1359-7345 Impact factor: 6.222