OBJECTIVE: The investigation into the course of ultra high risk (UHR) symptomatology of those patients who eventually do not meet the psychosis-threshold criteria within the 3-year timeframe of the study. METHOD: The course of UHR symptoms, GAF score and employment status was investigated in 57 patients who did not make a transition to psychosis and who were examined within the Dutch Prediction of Psychosis Study in Amsterdam, the Netherlands. RESULTS: At the 3-year follow-up, 75% of the patients who did not make a transition to psychosis had remitted from UHR status. With a Generalized Estimation Equation Model it was shown that this group recovered from positive (F = 52.7, P < 0.0001), negative (F = 24.3, P < 0.0001), disorganization (F = 14.4, P < 0.0001) and general symptoms (F = 25.0, P < 0.0001) within the timeframe of the study. In addition, the level of global functioning and likelihood of having a job and/or education significantly improved. The largest improvements occurred within the first year. UHR symptoms did not re-occur after improvement. CONCLUSION: With the current UHR criteria, a large percentage of the included subjects appear to have transitory complaints and dysfunctioning. A refinement of the UHR criteria may diminish the chance of including 'false positives' in future UHR studies.
OBJECTIVE: The investigation into the course of ultra high risk (UHR) symptomatology of those patients who eventually do not meet the psychosis-threshold criteria within the 3-year timeframe of the study. METHOD: The course of UHR symptoms, GAF score and employment status was investigated in 57 patients who did not make a transition to psychosis and who were examined within the Dutch Prediction of Psychosis Study in Amsterdam, the Netherlands. RESULTS: At the 3-year follow-up, 75% of the patients who did not make a transition to psychosis had remitted from UHR status. With a Generalized Estimation Equation Model it was shown that this group recovered from positive (F = 52.7, P < 0.0001), negative (F = 24.3, P < 0.0001), disorganization (F = 14.4, P < 0.0001) and general symptoms (F = 25.0, P < 0.0001) within the timeframe of the study. In addition, the level of global functioning and likelihood of having a job and/or education significantly improved. The largest improvements occurred within the first year. UHR symptoms did not re-occur after improvement. CONCLUSION: With the current UHR criteria, a large percentage of the included subjects appear to have transitory complaints and dysfunctioning. A refinement of the UHR criteria may diminish the chance of including 'false positives' in future UHR studies.
Authors: Scott W Woods; Barbara C Walsh; Jean Addington; Kristin S Cadenhead; Tyrone D Cannon; Barbara A Cornblatt; Robert Heinssen; Diana O Perkins; Larry J Seidman; Sarah I Tarbox; Ming T Tsuang; Elaine F Walker; Thomas H McGlashan Journal: Schizophr Res Date: 2014-07-08 Impact factor: 4.939
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Authors: D J Devoe; L Lu; T D Cannon; K S Cadenhead; B A Cornblatt; T H McGlashan; D O Perkins; L J Seidman; M T Tsuang; S W Woods; E F Walker; D H Mathalon; C E Bearden; J Addington Journal: Schizophr Res Date: 2020-04-30 Impact factor: 4.939
Authors: Sanne H Booij; Marieke Wichers; Peter de Jonge; Sjoerd Sytema; Jim van Os; Lex Wunderink; Johanna T W Wigman Journal: BMJ Open Date: 2018-01-21 Impact factor: 2.692
Authors: Stefania Tognin; William Pettersson-Yeo; Isabel Valli; Chloe Hutton; James Woolley; Paul Allen; Philip McGuire; Andrea Mechelli Journal: Front Psychiatry Date: 2014-01-29 Impact factor: 4.157
Authors: Fa Zhan Chen; Yi Wang; Xi Rong Sun; Yu Hong Yao; Ning Zhang; Hui Fen Qiao; Lan Zhang; Zhan Jiang Li; Hong Lin; Zheng Lu; Jing Li; Raymond C K Chan; Xu Dong Zhao Journal: Front Psychol Date: 2016-06-01
Authors: Gonzalo Salazar de Pablo; Livia Soardo; Anna Cabras; Joana Pereira; Simi Kaur; Filippo Besana; Vincenzo Arienti; Francesco Coronelli; Jae Il Shin; Marco Solmi; Natalia Petros; Andre F Carvalho; Philip McGuire; Paolo Fusar-Poli Journal: Epidemiol Psychiatr Sci Date: 2022-01-19 Impact factor: 6.892