Secondary amyloidosis in chronic osteomyelitis.

We report a longitudinal study to detect amyloidosis in 51 patients with chronic osteomyelitis which was carried out between 1986 and 1989 at our University Hospital in Nigeria. Biopsies of the sinus edge and rectal mucosa were carried out and stained specifically for amyloid deposits with Congo Red. Positive microscopic findings at one or other, but not at both sites were present in 5 cases (9.8%). Secondary amyloidosis is not common among patients with long standing suppurating osteomyelitis. When the suppuration is controlled or removed the amyloid deposits are absorbed.