Literature DB >> 20711235

Oncogenic function of the MUC1 receptor subunit in gene regulation.

D Kufe1.   

Abstract

The mucin 1 (MUC1) oncoprotein is overexpressed by diverse human cancers; however, it has remained largely unclear how MUC1 contributes to tumorigenesis. In this issue of Oncogene and in concert with published work, Behrens et al. report that the MUC1 receptor subunit activates genes involved in invasion, angiogenesis and metastasis.

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Year:  2010        PMID： 20711235      PMCID： PMC3615539          DOI： 10.1038/onc.2010.334

Source DB:  PubMed          Journal:  Oncogene        ISSN： 0950-9232            Impact factor:   9.867


  10 in total

1.  Direct targeting of the mucin 1 oncoprotein blocks survival and tumorigenicity of human breast carcinoma cells.

Authors:  Deepak Raina; Rehan Ahmad; Maya Datt Joshi; Li Yin; Zekui Wu; Takeshi Kawano; Baldev Vasir; David Avigan; Surender Kharbanda; Donald Kufe
Journal:  Cancer Res       Date:  2009-06-02       Impact factor: 12.701

2.  Human MUC1 oncoprotein regulates p53-responsive gene transcription in the genotoxic stress response.

Authors:  Xiaolong Wei; Hai Xu; Donald Kufe
Journal:  Cancer Cell       Date:  2005-02       Impact factor: 31.743

3.  MUC1 oncoprotein blocks glycogen synthase kinase 3beta-mediated phosphorylation and degradation of beta-catenin.

Authors:  Lei Huang; Dongshu Chen; Derek Liu; Li Yin; Surender Kharbanda; Donald Kufe
Journal:  Cancer Res       Date:  2005-11-15       Impact factor: 12.701

4.  Connective tissue growth factor is overexpressed in esophageal squamous cell carcinoma and promotes tumorigenicity through beta-catenin-T-cell factor/Lef signaling.

Authors:  Yue-Zhen Deng; Ping-Ping Chen; Yan Wang; Dong Yin; H Phillip Koeffler; Baojie Li; Xiang-Jun Tong; Dong Xie
Journal:  J Biol Chem       Date:  2007-10-21       Impact factor: 5.157

5.  MUC1-induced alterations in a lipid metabolic gene network predict response of human breast cancers to tamoxifen treatment.

Authors:  Sean P Pitroda; Nikolai N Khodarev; Michael A Beckett; Donald W Kufe; Ralph R Weichselbaum
Journal:  Proc Natl Acad Sci U S A       Date:  2009-03-16       Impact factor: 11.205

Review 6.  Mucins in cancer: function, prognosis and therapy.

Authors:  Donald W Kufe
Journal:  Nat Rev Cancer       Date:  2009-12       Impact factor: 60.716

7.  The MUC1 and galectin-3 oncoproteins function in a microRNA-dependent regulatory loop.

Authors:  Selvi Ramasamy; Sekhar Duraisamy; Sergei Barbashov; Takeshi Kawano; Surender Kharbanda; Donald Kufe
Journal:  Mol Cell       Date:  2007-09-21       Impact factor: 17.970

8.  MUC1-induced transcriptional programs associated with tumorigenesis predict outcome in breast and lung cancer.

Authors:  Nikolai N Khodarev; Sean P Pitroda; Michael A Beckett; Dhara M MacDermed; Lei Huang; Donald W Kufe; Ralph R Weichselbaum
Journal:  Cancer Res       Date:  2009-03-24       Impact factor: 12.701

9.  The reactive tumor microenvironment: MUC1 signaling directly reprograms transcription of CTGF.

Authors:  M E Behrens; P M Grandgenett; J M Bailey; P K Singh; C-H Yi; F Yu; M A Hollingsworth
Journal:  Oncogene       Date:  2010-08-09       Impact factor: 9.867

10.  Cooperativity of the MUC1 oncoprotein and STAT1 pathway in poor prognosis human breast cancer.

Authors:  N Khodarev; R Ahmad; H Rajabi; S Pitroda; T Kufe; C McClary; M D Joshi; D MacDermed; R Weichselbaum; D Kufe
Journal:  Oncogene       Date:  2009-11-16       Impact factor: 9.867
  10 in total
  14 in total

Review 1.  MUC1 and MUC4: switching the emphasis from large to small.

Authors:  Huguette Albrecht; Kermit L Carraway
Journal:  Cancer Biother Radiopharm       Date:  2011-06       Impact factor: 3.099

2.  MUC1-C oncoprotein confers androgen-independent growth of human prostate cancer cells.

Authors:  Hasan Rajabi; Rehan Ahmad; Caining Jin; Maya Datt Joshi; Minakshi Guha; Maroof Alam; Surender Kharbanda; Donald Kufe
Journal:  Prostate       Date:  2012-04-02       Impact factor: 4.104

3.  Targeting cysteine-mediated dimerization of the MUC1-C oncoprotein in human cancer cells.

Authors:  Deepak Raina; Rehan Ahmad; Hasan Rajabi; Govind Panchamoorthy; Surender Kharbanda; Donald Kufe
Journal:  Int J Oncol       Date:  2011-12-20       Impact factor: 5.650

Review 4.  Tumour-associated antigens: considerations for their use in tumour immunotherapy.

Authors:  Adam J Linley; Murrium Ahmad; Robert C Rees
Journal:  Int J Hematol       Date:  2011-03-01       Impact factor: 2.490

5.  Core 3 mucin-type O-glycan restoration in colorectal cancer cells promotes MUC1/p53/miR-200c-dependent epithelial identity.

Authors:  J Ye; X Wei; Y Shang; Q Pan; M Yang; Y Tian; Y He; Z Peng; L Chen; W Chen; R Wang
Journal:  Oncogene       Date:  2017-07-24       Impact factor: 9.867

Review 6.  Usefulness of traditional serum biomarkers for management of breast cancer patients.

Authors:  Peppino Mirabelli; Mariarosaria Incoronato
Journal:  Biomed Res Int       Date:  2013-11-07       Impact factor: 3.411

7.  MUC1c regulates cell survival in pancreatic cancer by preventing lysosomal permeabilization.

Authors:  Sulagna Banerjee; Nameeta Mujumdar; Vikas Dudeja; Tiffany Mackenzie; Tara K Krosch; Veena Sangwan; Selwyn M Vickers; Ashok K Saluja
Journal:  PLoS One       Date:  2012-08-13       Impact factor: 3.240

Review 8.  MUC1-specific cytotoxic T lymphocytes in cancer therapy: induction and challenge.

Authors:  David Roulois; Marc Grégoire; Jean-François Fonteneau
Journal:  Biomed Res Int       Date:  2012-12-26       Impact factor: 3.411

9.  Natural and Induced Humoral Responses to MUC1.

Authors:  Silvia Von Mensdorff-Pouilly; Maria Moreno; René H M Verheijen
Journal:  Cancers (Basel)       Date:  2011-07-29       Impact factor: 6.639

10.  Targeting DNGR-1 (CLEC9A) with antibody/MUC1 peptide conjugates as a vaccine for carcinomas.

Authors:  Gianfranco Picco; Richard Beatson; Joyce Taylor-Papadimitriou; Joy M Burchell
Journal:  Eur J Immunol       Date:  2014-04-17       Impact factor: 5.532
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