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Literature DB >> 20711227

Therapeutic implications of chemokine-mediated pathways in atherosclerosis: realistic perspectives and utopias.

Stavros Apostolakis¹, Virginia Amanatidou, Demetrios A Spandidos.

Abstract

Current perspectives on the pathogenesis of atherosclerosis strongly support the involvement of inflammatory mediators in the establishment and progression of atherosclerostic lesions. Chemokine-mediated mechanisms are potent regulators of such processes by orchestrating the interactions of inflammatory cellular components of the peripheral blood with cellular components of the arterial wall. The increasing evidence supporting the role of chemokine pathways in atherosclerosis renders chemokine ligands and their receptors potential therapeutic targets. In the following review, we aim to highlight the special structural and functional features of chemokines and their receptors in respect to their roles in atherosclerosis, and examine to what extent available data can be applied in disease management practices.

Entities: Disease

Mesh：

Substances：

Year: 2010 PMID： 20711227 PMCID： PMC4002307 DOI： 10.1038/aps.2010.131

Source DB: PubMed Journal: Acta Pharmacol Sin ISSN： 1671-4083 Impact factor: 6.150

64 in total

1. Chemokine fractalkine mediates leukocyte recruitment to inflammatory endothelial cells in flowing whole blood: a critical role for P-selectin expressed on activated platelets.

Authors: Christian Schulz; Andreas Schäfer; Moritz Stolla; Sandra Kerstan; Michael Lorenz; Marie-Luise von Brühl; Matthias Schiemann; Johann Bauersachs; Torsten Gloe; Dirk H Busch; Meinrad Gawaz; Steffen Massberg
Journal: Circulation Date: 2007-08-06 Impact factor: 29.690

Review 2. Platelets as immune cells: bridging inflammation and cardiovascular disease.

Authors: Philipp von Hundelshausen; Christian Weber
Journal: Circ Res Date: 2007-01-05 Impact factor: 17.367

Review 3. Chemokine regulation of atherosclerosis.

Authors: Jana Barlic; Philip M Murphy
Journal: J Leukoc Biol Date: 2007-03-29 Impact factor: 4.962

Review 4. Chemokines in vascular pathology (review).

Authors: Stavros Apostolakis; Emmanouil G Papadakis; Elias Krambovitis; Demetrios A Spandidos
Journal: Int J Mol Med Date: 2006-05 Impact factor: 4.101

5. Structural determinants of MIF functions in CXCR2-mediated inflammatory and atherogenic leukocyte recruitment.

Authors: Christian Weber; Sandra Kraemer; Maik Drechsler; Hongqi Lue; Rory R Koenen; Aphrodite Kapurniotu; Alma Zernecke; Jürgen Bernhagen
Journal: Proc Natl Acad Sci U S A Date: 2008-10-13 Impact factor: 11.205

6. Fractalkine deficiency markedly reduces macrophage accumulation and atherosclerotic lesion formation in CCR2-/- mice: evidence for independent chemokine functions in atherogenesis.

Authors: Noah Saederup; Liana Chan; Sergio A Lira; Israel F Charo
Journal: Circulation Date: 2007-12-28 Impact factor: 29.690

7. Modulation of CCR2 in rheumatoid arthritis: a double-blind, randomized, placebo-controlled clinical trial.

Authors: Clarissa E Vergunst; Daniëlle M Gerlag; Luba Lopatinskaya; L Klareskog; M D Smith; F van den Bosch; Huib J Dinant; Yih Lee; Timothy Wyant; Eric W Jacobson; Dominique Baeten; Paul P Tak
Journal: Arthritis Rheum Date: 2008-07

8. Serial measurement of monocyte chemoattractant protein-1 after acute coronary syndromes: results from the A to Z trial.

Authors: James A de Lemos; David A Morrow; Michael A Blazing; Petr Jarolim; Stephen D Wiviott; Marc S Sabatine; Robert M Califf; Eugene Braunwald
Journal: J Am Coll Cardiol Date: 2007-11-13 Impact factor: 24.094

9. Fractalkine upregulates intercellular adhesion molecule-1 in endothelial cells through CX3CR1 and the Jak Stat5 pathway.

Authors: Xiao Ping Yang; Subhendra Mattagajasingh; Shaobo Su; Guibin Chen; Zheqing Cai; Karen Fox-Talbot; Kaikobad Irani; Lewis C Becker
Journal: Circ Res Date: 2007-09-20 Impact factor: 17.367

10. CX3CR1 receptor is up-regulated in monocytes of coronary artery diseased patients: impact of pre-inflammatory stimuli and renin-angiotensin system modulators.

Authors: Stavros Apostolakis; Elias Krambovitis; Zaharenia Vlata; Georgios E Kochiadakis; Stavroula Baritaki; Demetrios A Spandidos
Journal: Thromb Res Date: 2007-05-23 Impact factor: 3.944

6 in total

Therapeutic implications of chemokine-mediated pathways in atherosclerosis: realistic perspectives and utopias.

1. Chemokine fractalkine mediates leukocyte recruitment to inflammatory endothelial cells in flowing whole blood: a critical role for P-selectin expressed on activated platelets.

Review 2. Platelets as immune cells: bridging inflammation and cardiovascular disease.

Review 3. Chemokine regulation of atherosclerosis.

Review 4. Chemokines in vascular pathology (review).

5. Structural determinants of MIF functions in CXCR2-mediated inflammatory and atherogenic leukocyte recruitment.

6. Fractalkine deficiency markedly reduces macrophage accumulation and atherosclerotic lesion formation in CCR2-/- mice: evidence for independent chemokine functions in atherogenesis.

7. Modulation of CCR2 in rheumatoid arthritis: a double-blind, randomized, placebo-controlled clinical trial.

8. Serial measurement of monocyte chemoattractant protein-1 after acute coronary syndromes: results from the A to Z trial.

9. Fractalkine upregulates intercellular adhesion molecule-1 in endothelial cells through CX3CR1 and the Jak Stat5 pathway.

10. CX3CR1 receptor is up-regulated in monocytes of coronary artery diseased patients: impact of pre-inflammatory stimuli and renin-angiotensin system modulators.

1. Leukocyte chemoattractant receptor FPR2 may accelerate atherogenesis.

Review 2. The Role of CXC Chemokines in Cardiovascular Diseases.

Review 3. Chemokines and atherosclerosis: focus on the CX3CL1/CX3CR1 pathway.

Review 4. Chemokines and Their Receptors Are Key Players in the Orchestra That Regulates Wound Healing.

5. The Interaction between Fluid Wall Shear Stress and Solid Circumferential Strain Affects Endothelial Gene Expression.

6. Lipoprotein redox status evaluation as a marker of cardiovascular disease risk in patients with inflammatory disease.