Literature DB >> 2071029

Reactivity of phospholipid hydroperoxide glutathione peroxidase with membrane and lipoprotein lipid hydroperoxides.

M Maiorino1, J P Thomas, A W Girotti, F Ursini.   

Abstract

A comparative study has been carried out on the general reactivity of lipid hydroperoxides in liposomes, biological membranes and lipoproteins with two Se-dependent peroxidases: Glutathione Peroxidase (GPX) and Phospholipid Hydroperoxide Glutathione Peroxidase (PHGPX). While PHGPX reduces all hydroperoxides derived from phospholipids, cholesterol and cholesterol esters, GPX reduces only fatty acid hydroperoxides released after treatment of phospholipid hydroperoxides with phospholipase A2. These findings highlight the role of PHGPX in protecting biomembranes from peroxidative damage and add new insight into how cholesterol hydroperoxides are detossified in cells.

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Year:  1991        PMID： 2071029     DOI： 10.3109/10715769109145777

Source DB:  PubMed          Journal:  Free Radic Res Commun        ISSN： 8755-0199


  15 in total

1.  Cell growth potential drives ferroptosis susceptibility in rhabdomyosarcoma and myoblast cell lines.

Authors:  Silvia Codenotti; Maura Poli; Michela Asperti; Daniela Zizioli; Francesco Marampon; Alessandro Fanzani
Journal:  J Cancer Res Clin Oncol       Date:  2018-07-03       Impact factor: 4.553

2.  Effect of selenium-deficient diet on tubular epithelium in normal rats.

Authors:  Mikiya Fujieda; Keishi Naruse; Tadashi Hamauzu; Eriko Miyazaki; Yoshihiro Hayashi; Riyo Enomoto; Eibai Lee; Kazuhide Ohta; Yutaka Yamaguchi; Hiroshi Wakiguchi; Hideaki Enza
Journal:  Pediatr Nephrol       Date:  2006-11-16       Impact factor: 3.714

3.  Impact of acute Cd²⁺ exposure on the antioxidant defence systems in the skin and red blood cells of common carp (Cyprinus carpio).

Authors:  Ágnes Ferencz; Edit Hermesz
Journal:  Environ Sci Pollut Res Int       Date:  2014-12-05       Impact factor: 4.223

4.  Function and regulation of the glutathione peroxidase homologous gene GPXH/GPX5 in Chlamydomonas reinhardtii.

Authors:  Beat B Fischer; Régine Dayer; Yvonne Schwarzenbach; Stéphane D Lemaire; Renata Behra; Anja Liedtke; Rik I L Eggen
Journal:  Plant Mol Biol       Date:  2009-12       Impact factor: 4.076

5.  Human blood cells support the reduction of low-density-lipoprotein-associated cholesteryl ester hydroperoxides by albumin-bound ebselen.

Authors:  J Christison; H Sies; R Stocker
Journal:  Biochem J       Date:  1994-12-01       Impact factor: 3.857

6.  Functional characterization of cis- and trans-regulatory elements involved in expression of phospholipid hydroperoxide glutathione peroxidase.

Authors:  Christoph Ufer; Astrid Borchert; Hartmut Kuhn
Journal:  Nucleic Acids Res       Date:  2003-08-01       Impact factor: 16.971

7.  Influence of n-3 fatty acids on the growth of human breast cancer cells in vitro: relationship to peroxides and vitamin-E.

Authors:  V Chajès; W Sattler; A Stranzl; G M Kostner
Journal:  Breast Cancer Res Treat       Date:  1995-06       Impact factor: 4.872

Review 8.  The peroxiredoxin and glutathione peroxidase families in Chlamydomonas reinhardtii.

Authors:  Régine Dayer; Beat B Fischer; Rik I L Eggen; Stéphane D Lemaire
Journal:  Genetics       Date:  2008-05       Impact factor: 4.562

9.  Mitochondrial metabolism of a hydroperoxide to free radicals in human endothelial cells: an electron spin resonance spin-trapping investigation.

Authors:  V O'Donnell; M J Burkitt
Journal:  Biochem J       Date:  1994-12-15       Impact factor: 3.857

Review 10.  Selenoproteins in Tumorigenesis and Cancer Progression.

Authors:  Sarah P Short; Christopher S Williams
Journal:  Adv Cancer Res       Date:  2017       Impact factor: 6.242
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