| Literature DB >> 20709545 |
Sriram Tyagarajan1, Prasun K Chakravarty, Bishan Zhou, Brett Taylor, Michael H Fisher, Mathew J Wyvratt, Kathy Lyons, Tracy Klatt, Xiaohua Li, Sanjeev Kumar, Brande Williams, John Felix, Birgit T Priest, Richard M Brochu, Vivien Warren, McHardy Smith, Maria Garcia, Gregory J Kaczorowski, William J Martin, Catherine Abbadie, Erin McGowan, Nina Jochnowitz, William H Parsons.
Abstract
Voltage-gated sodium channels have been shown to play a critical role in neuropathic pain. A series of low molecular weight biaryl substituted pyrazole carboxamides were identified with good in-vitro potency and in-vivo efficacy. Compound 26, a Nav1.7 blocker has excellent efficacy in the Chung model of neuropathic pain. Copyright (c) 2010 Elsevier Ltd. All rights reserved.Entities:
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Year: 2010 PMID： 20709545 DOI： 10.1016/j.bmcl.2010.07.080
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823