Literature DB >> 20709413

Proliferative and protective effects of SurR9-C84A on differentiated neural cells.

Sara Baratchi1, Rupinder K Kanwar, Chun Hei Antonio Cheung, Jagat R Kanwar.   

Abstract

Targeting survivin has the ability to inhibit apoptosis and regulate mitosis for the protection of neuronal cells, and it offers several advantages for neuronal repair and protection. We found that the BIR motif mutant of survivin (SurR9-C84A) can bind to microtubules and regulate their stability, induce cell division, increase proliferation and activate the expression of cell cycle and neuronal markers in differentiated SK-N-SH and HCN-2 neurons. We further showed the protective effects of SurR9-C84A against post differentiation retinoic acid induced neurotoxicity. These abilities of SurR9-C84A offer a great potential for future neuronal repair therapy. Crown
Copyright © 2010. Published by Elsevier B.V. All rights reserved.

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Year:  2010        PMID： 20709413     DOI： 10.1016/j.jneuroim.2010.06.024

Source DB:  PubMed          Journal:  J Neuroimmunol        ISSN： 0165-5728            Impact factor:   3.478


  8 in total

1.  Nanoformulated Mutant SurR9-C84A: a Possible Key for Alzheimer's and its Associated Inflammation.

Authors:  Bhasker Sriramoju; Rupinder K Kanwar; Jagat R Kanwar
Journal:  Pharm Res       Date:  2015-03-14       Impact factor: 4.200

2.  Survivin mutant protects differentiated dopaminergic SK-N-SH cells against oxidative stress.

Authors:  Sara Baratchi; Rupinder K Kanwar; Jagat R Kanwar
Journal:  PLoS One       Date:  2011-01-10       Impact factor: 3.240

3.  Competitive inhibition of survivin using a cell-permeable recombinant protein induces cancer-specific apoptosis in colon cancer model.

Authors:  Kislay Roy; Rupinder K Kanwar; Subramanian Krishnakumar; Chun Hei Antonio Cheung; Jagat R Kanwar
Journal:  Int J Nanomedicine       Date:  2015-02-02

4.  Cissus quadrangularis inhibits IL-1β induced inflammatory responses on chondrocytes and alleviates bone deterioration in osteotomized rats via p38 MAPK signaling.

Authors:  Jagat R Kanwar; Rasika M Samarasinghe; Kuldeep Kumar; Ramesh Arya; Sanjeev Sharma; Shu-Feng Zhou; Sreenivasan Sasidharan; Rupinder K Kanwar
Journal:  Drug Des Devel Ther       Date:  2015-06-05       Impact factor: 4.162

5.  Nanoformulated cell-penetrating survivin mutant and its dual actions.

Authors:  Bhasker Sriramoju; Rupinder K Kanwar; Jagat R Kanwar
Journal:  Int J Nanomedicine       Date:  2014-07-10

6.  Topical Ophthalmic Formulation of Trichostatin A and SurR9-C84A for Quick Recovery Post-alkali Burn of Corneal Haze.

Authors:  Kislay Roy; Prasad Neerati; Chun Hei Antonio Cheung; Rupinder K Kanwar; Rajat Sandhir; Jagat R Kanwar
Journal:  Front Pharmacol       Date:  2017-05-05       Impact factor: 5.810

Review 7.  Neurological disorders and therapeutics targeted to surmount the blood-brain barrier.

Authors:  Jagat R Kanwar; Bhasker Sriramoju; Rupinder K Kanwar
Journal:  Int J Nanomedicine       Date:  2012-07-09

8.  Ophthalmic Combination of SurR9-C84A and Trichostatin-A Targeting Molecular Pathogenesis of Alkali Burn.

Authors:  Kislay Roy; Bhasker Sriramoju; Rupinder K Kanwar; Jagat R Kanwar
Journal:  Front Pharmacol       Date:  2016-07-28       Impact factor: 5.810
  8 in total

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