Literature DB >> 20708904

Intramuscular and intravenous levetiracetam in humans: safety and pharmacokinetics.

Ilo E Leppik1, Varun Goel, John Rarick, Donald R Nixdorf, James C Cloyd.   

Abstract

A study in dogs demonstrated that the commercially available formulation of IV levetiracetam (LEV) could be given safely IM and was quickly and completely absorbed. In this crossover study, 5 women and 5 men were given IM and IV LEV. This study demonstrates that administration of 5ml (500mg) IM LEV is well tolerated and its bioavailability is equivalent to an IV injection.
Copyright © 2010 Elsevier B.V. All rights reserved.

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Year:  2010        PMID: 20708904     DOI: 10.1016/j.eplepsyres.2010.07.016

Source DB:  PubMed          Journal:  Epilepsy Res        ISSN: 0920-1211            Impact factor:   3.045


  3 in total

Review 1.  Intravenous and Intramuscular Formulations of Antiseizure Drugs in the Treatment of Epilepsy.

Authors:  Sima I Patel; Angela K Birnbaum; James C Cloyd; Ilo E Leppik
Journal:  CNS Drugs       Date:  2015-12       Impact factor: 5.749

Review 2.  Clinical pharmacology and pharmacokinetics of levetiracetam.

Authors:  Chanin Wright; Jana Downing; Diana Mungall; Owais Khan; Amanda Williams; Ekokobe Fonkem; Darin Garrett; Jose Aceves; Batool Kirmani
Journal:  Front Neurol       Date:  2013-12-04       Impact factor: 4.003

3.  Author's Reply to: "Comment on: Pharmacokinetics and Safety of Recombinant Human Interleukin-1 Receptor Antagonist GR007 in Chinese Healthy Subjects".

Authors:  Ran Xie; Yang Zhang; Nan Zhao; Shuang Zhou; Xin Wang; Wei Han; Yan Yu; Xia Zhao; Yimin Cui
Journal:  Eur J Drug Metab Pharmacokinet       Date:  2019-10       Impact factor: 2.441

  3 in total

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