Literature DB >> 20708657

The inhibitory effects of Gelam honey and its extracts on nitric oxide and prostaglandin E(2) in inflammatory tissues.

Mustafa Kassim1, Mouna Achoui, Marzida Mansor, Kamaruddin Mohd Yusoff.   

Abstract

We investigated the effects of honey and its methanol and ethyl acetate extracts on inflammation in animal models. Rats' paws were induced with carrageenan in the non-immune inflammatory and nociceptive model, and lipopolysaccharide (LPS) in the immune inflammatory model. Honey and its extracts were able to inhibit edema and pain in inflammatory tissues as well as showing potent inhibitory activities against NO and PGE(2) in both models. The decrease in edema and pain correlates with the inhibition of NO and PGE(2). Phenolic compounds have been implicated in the inhibitory activities. Honey is potentially useful in the treatment of inflammatory conditions.
Copyright © 2010 Elsevier B.V. All rights reserved.

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Year:  2010        PMID： 20708657     DOI： 10.1016/j.fitote.2010.07.024

Source DB:  PubMed          Journal:  Fitoterapia        ISSN： 0367-326X            Impact factor:   2.882


  29 in total

1.  Analgesic and anti-inflammatory effects of honey: the involvement of autonomic receptors.

Authors:  Bamidele Victor Owoyele; Rasheed Olajiire Oladejo; Kayode Ajomale; Rasheedat Omotayo Ahmed; Abdulrasheed Mustapha
Journal:  Metab Brain Dis       Date:  2013-12-10       Impact factor: 3.584

2.  Sinapic Acid Ameliorates Acetic Acid-Induced Ulcerative Colitis in Rats by Suppressing Inflammation, Oxidative Stress, and Apoptosis.

Authors:  Mudassar Shahid; Mohammad Raish; Ajaz Ahmad; Yousef A Bin Jardan; Mushtaq Ahmad Ansari; Abdul Ahad; Khalid M Alkharfy; Ahmed L Alaofi; Fahad I Al-Jenoobi
Journal:  Molecules       Date:  2022-06-28       Impact factor: 4.927

3.  The antioxidant effect of the Malaysian Gelam honey on pancreatic hamster cells cultured under hyperglycemic conditions.

Authors:  Kalaivani Batumalaie; Rajes Qvist; Kamaruddin Mohd Yusof; Ikram Shah Ismail; Shamala Devi Sekaran
Journal:  Clin Exp Med       Date:  2013-04-13       Impact factor: 3.984

4.  Histopathological and Inflammatory Features of Chronically Discharging Open Mastoid Cavities: Secondary Analysis of a Randomized Clinical Trial.

Authors:  Darius Henatsch; Sultan Alsulami; Adriaan M Duijvestijn; Jack P Cleutjens; Carine J Peutz-Kootstra; Robert J Stokroos
Journal:  JAMA Otolaryngol Head Neck Surg       Date:  2018-03-01       Impact factor: 6.223

5.  Gelam honey attenuates carrageenan-induced rat paw inflammation via NF-κB pathway.

Authors:  Saba Zuhair Hussein; Kamaruddin Mohd Yusoff; Suzana Makpol; Yasmin Anum Mohd Yusof
Journal:  PLoS One       Date:  2013-08-28       Impact factor: 3.240

6.  Gelam (Melaleuca spp.) Honey-Based Hydrogel as Burn Wound Dressing.

Authors:  Rozaini Mohd Zohdi; Zuki Abu Bakar Zakaria; Norimah Yusof; Noordin Mohamed Mustapha; Muhammad Nazrul Hakim Abdullah
Journal:  Evid Based Complement Alternat Med       Date:  2011-09-19       Impact factor: 2.629

7.  Gelam honey has a protective effect against lipopolysaccharide (LPS)-induced organ failure.

Authors:  Mustafa Kassim; Marzida Mansor; Nazeh Al-Abd; Kamaruddin Mohd Yusoff
Journal:  Int J Mol Sci       Date:  2012-05-23       Impact factor: 6.208

8.  Intestinal microbiota, probiotics and mental health: from Metchnikoff to modern advances: Part II - contemporary contextual research.

Authors:  Alison C Bested; Alan C Logan; Eva M Selhub
Journal:  Gut Pathog       Date:  2013-03-14       Impact factor: 4.181

9.  Gelam Honey Inhibits the Production of Proinflammatory, Mediators NO, PGE(2), TNF-α, and IL-6 in Carrageenan-Induced Acute Paw Edema in Rats.

Authors:  Saba Zuhair Hussein; Kamaruddin Mohd Yusoff; Suzana Makpol; Yasmin Anum Mohd Yusof
Journal:  Evid Based Complement Alternat Med       Date:  2012-07-01       Impact factor: 2.629

10.  Gelam honey scavenges peroxynitrite during the immune response.

Authors:  Mustafa Kassim; Marzida Mansor; Anwar Suhaimi; Gracie Ong; Kamaruddin Mohd Yusoff
Journal:  Int J Mol Sci       Date:  2012-09-24       Impact factor: 6.208
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