Literature DB >> 20708579

Tuning mTORC1 activity for balanced self-renewal and differentiation.

Larissa S Carnevalli1, Andreas Trumpp.   

Abstract

Understanding the mechanisms that control stem cell self-renewal and differentiation are at the core of stem cell biology. In a recent issue of Cell, Hobbs et al. report that harnessing mTORC1 activity by the transcription factor PLZF is crucial to maintain the self-renewing activity of germline progenitors.
Copyright © 2010 Elsevier Inc. All rights reserved.

Entities:  

Year:  2010        PMID： 20708579     DOI： 10.1016/j.devcel.2010.08.001

Source DB:  PubMed          Journal:  Dev Cell        ISSN： 1534-5807            Impact factor:   12.270


  3 in total

1.  CIP2A promotes proliferation of spermatogonial progenitor cells and spermatogenesis in mice.

Authors:  Sami Ventelä; Christophe Côme; Juho-Antti Mäkelä; Robin M Hobbs; Leni Mannermaa; Markku Kallajoki; Edward K Chan; Pier Paolo Pandolfi; Jorma Toppari; Jukka Westermarck
Journal:  PLoS One       Date:  2012-03-26       Impact factor: 3.240

2.  PLZFposc-KITpos-delineated A1-A4-differentiating spermatogonia by subset and stage detection upon Bouin fixation.

Authors:  Rui-Ling Tang; Li-Qing Fan
Journal:  Asian J Androl       Date:  2019 May-Jun       Impact factor: 3.285

Review 3.  Metabolic Requirements for Spermatogonial Stem Cell Establishment and Maintenance In Vivo and In Vitro.

Authors:  Anna Laura Voigt; Shiama Thiageswaran; Nathalia de Lima E Martins Lara; Ina Dobrinski
Journal:  Int J Mol Sci       Date:  2021-02-18       Impact factor: 5.923
  3 in total

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