Literature DB >> 20708578

Getting one's Fak straight.

Gerard Evan1.   

Abstract

Focal adhesion kinase (FAK) is a pivotal regulator of integrin signaling and responses to cell adhesive dynamics. In this issue of Developmental Cell, Ashton et al. demonstrate that Fak is critical for intestinal oncogenesis and regeneration after injury but not for day-to-day homeostasis, providing novel insights into intestinal biology and colorectal cancer therapy. 2010 Elsevier Inc. All rights reserved.

Entities:  

Year:  2010        PMID： 20708578      PMCID： PMC2967025          DOI： 10.1016/j.devcel.2010.07.023

Source DB:  PubMed          Journal:  Dev Cell        ISSN： 1534-5807            Impact factor:   12.270


  7 in total

1.  The beta-catenin/TCF-4 complex imposes a crypt progenitor phenotype on colorectal cancer cells.

Authors:  Marc van de Wetering; Elena Sancho; Cornelis Verweij; Wim de Lau; Irma Oving; Adam Hurlstone; Karin van der Horn; Eduard Batlle; Damien Coudreuse; Anna Pavlina Haramis; Menno Tjon-Pon-Fong; Petra Moerer; Maaike van den Born; Gwen Soete; Steven Pals; Martin Eilers; Rene Medema; Hans Clevers
Journal:  Cell       Date:  2002-10-18       Impact factor: 41.582

2.  Beta-catenin and TCF mediate cell positioning in the intestinal epithelium by controlling the expression of EphB/ephrinB.

Authors:  Eduard Batlle; Jeffrey T Henderson; Harry Beghtel; Maaike M W van den Born; Elena Sancho; Gerwin Huls; Jan Meeldijk; Jennifer Robertson; Marc van de Wetering; Tony Pawson; Hans Clevers
Journal:  Cell       Date:  2002-10-18       Impact factor: 41.582

3.  c-Myc is required for the formation of intestinal crypts but dispensable for homeostasis of the adult intestinal epithelium.

Authors:  Michael D Bettess; Nicole Dubois; Mark J Murphy; Christelle Dubey; Catherine Roger; Sylvie Robine; Andreas Trumpp
Journal:  Mol Cell Biol       Date:  2005-09       Impact factor: 4.272

4.  Identification of c-MYC as a target of the APC pathway.

Authors:  T C He; A B Sparks; C Rago; H Hermeking; L Zawel; L T da Costa; P J Morin; B Vogelstein; K W Kinzler
Journal:  Science       Date:  1998-09-04       Impact factor: 47.728

5.  Modelling Myc inhibition as a cancer therapy.

Authors:  Laura Soucek; Jonathan Whitfield; Carla P Martins; Andrew J Finch; Daniel J Murphy; Nicole M Sodir; Anthony N Karnezis; Lamorna Brown Swigart; Sergio Nasi; Gerard I Evan
Journal:  Nature       Date:  2008-08-17       Impact factor: 49.962

6.  Distinct thresholds govern Myc's biological output in vivo.

Authors:  Daniel J Murphy; Melissa R Junttila; Laurent Pouyet; Anthony Karnezis; Ksenya Shchors; Duyen A Bui; Lamorna Brown-Swigart; Leisa Johnson; Gerard I Evan
Journal:  Cancer Cell       Date:  2008-12-09       Impact factor: 31.743

7.  Rapid loss of intestinal crypts upon conditional deletion of the Wnt/Tcf-4 target gene c-Myc.

Authors:  Vanesa Muncan; Owen J Sansom; Leon Tertoolen; Toby J Phesse; Harry Begthel; Elena Sancho; Alicia M Cole; Alex Gregorieff; Ignacio Moreno de Alboran; Hans Clevers; Alan R Clarke
Journal:  Mol Cell Biol       Date:  2006-09-05       Impact factor: 4.272
  7 in total
  2 in total

1.  Advancing biomaterials of human origin for tissue engineering.

Authors:  Fa-Ming Chen; Xiaohua Liu
Journal:  Prog Polym Sci       Date:  2015-03-28       Impact factor: 29.190

2.  Overexpression of focal adhesion kinase correlates with increased lymph node metastasis and poor prognosis in non-small-cell lung cancer.

Authors:  Hong-Fei Ji; Da Pang; Song-Bin Fu; Yan Jin; Lei Yao; Ji-Ping Qi; Jing Bai
Journal:  J Cancer Res Clin Oncol       Date:  2012-11-11       Impact factor: 4.553
  2 in total

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