BACKGROUND: Matrix metalloproteinases (MMPs) are involved in cardiac remodeling and are encoded by genes showing genetic polymorphisms that have functional implications. We examined whether MMP-9 genetic polymorphisms are associated with hypertension and with left ventricular (LV) remodeling in hypertensive patients. METHODS: We studied 173 hypertensive patients and 137 age, race and gender matched healthy controls. Heart echocardiography was performed in all patients and the following MMP-9 genetic polymorphisms were analyzed: C(-1562)T (rs3918242), -90 (CA)(14-24) (rs2234681) and Q279R (rs17576). Haplo.stats analysis was used to assess whether MMP-9 haplotypes are associated with hypertension. Linear regression analysis was performed to assess whether MMP-9 haplotypes affect LV mass index (LVMI) and other echocardiography parameters. RESULTS: MMP-9 -90 (CA)(14-24) "HH" genotype (H allele defined by number of CA repeats ≥21) was associated with hypertension (P=0.0085; OR=2.321, 95% confidence interval=1.250 to 4.309). While one MMP-9 haplotype ("C, H, Q") protects against LVMI and end-diastolic diameter increases due to remodeling (P=0.0490 and P=0.0367), another MMP-9 haplotype apparently has detrimental effects over both parameters in hypertensive patients ("T, H, Q", P=0.0015 and P=0.0057, respectively). CONCLUSION: Genetic polymorphisms in MMP-9 gene may modify the susceptibility of hypertensive patients to LV remodeling. Further studies are necessary to examine whether these polymorphisms affect clinical events in hypertensive patients.
BACKGROUND: Matrix metalloproteinases (MMPs) are involved in cardiac remodeling and are encoded by genes showing genetic polymorphisms that have functional implications. We examined whether MMP-9 genetic polymorphisms are associated with hypertension and with left ventricular (LV) remodeling in hypertensivepatients. METHODS: We studied 173 hypertensivepatients and 137 age, race and gender matched healthy controls. Heart echocardiography was performed in all patients and the following MMP-9 genetic polymorphisms were analyzed: C(-1562)T (rs3918242), -90 (CA)(14-24) (rs2234681) and Q279R (rs17576). Haplo.stats analysis was used to assess whether MMP-9 haplotypes are associated with hypertension. Linear regression analysis was performed to assess whether MMP-9 haplotypes affect LV mass index (LVMI) and other echocardiography parameters. RESULTS:MMP-9 -90 (CA)(14-24) "HH" genotype (H allele defined by number of CA repeats ≥21) was associated with hypertension (P=0.0085; OR=2.321, 95% confidence interval=1.250 to 4.309). While one MMP-9 haplotype ("C, H, Q") protects against LVMI and end-diastolic diameter increases due to remodeling (P=0.0490 and P=0.0367), another MMP-9 haplotype apparently has detrimental effects over both parameters in hypertensivepatients ("T, H, Q", P=0.0015 and P=0.0057, respectively). CONCLUSION: Genetic polymorphisms in MMP-9 gene may modify the susceptibility of hypertensivepatients to LV remodeling. Further studies are necessary to examine whether these polymorphisms affect clinical events in hypertensivepatients.
Authors: Paulo R Mendes; Tatiana A Kiyota; José A Cipolli; Roberto Schreiber; Layde R Paim; Vera R Bellinazzi; José R Matos-Souza; Andrei C Sposito; Wilson Nadruz Journal: Hypertens Res Date: 2014-11-27 Impact factor: 3.872
Authors: Marcelo R Luizon; Vanessa A Belo; Karla S Fernandes; Vanessa L Andrade; Jose E Tanus-Santos; Valeria C Sandrim Journal: Mol Biol Rep Date: 2016-05-05 Impact factor: 2.316
Authors: Walter E M Rocha; Matheus F R A Oliveira; Julia D Soares; Victor M F S L'Armée; Mayara P G Martins; Aloísio M Rocha; Audes D M Feitosa; Ricardo C Lima; Pedro P M Oliveira; Lindemberg M Silveira-Filho; Otavio R Coelho-Filho; José R Matos-Souza; Orlando Petrucci; Andrei C Sposito; Wilson Nadruz Journal: J Am Heart Assoc Date: 2021-02-18 Impact factor: 5.501
Authors: Ashraf Galal; Fatina I Fadel; Enas Mokhtar; Manal F Elshamaa; Eman A Elghoroury; Solaf Kamel; Gamila S M Elsaeed; Eman H Thabet Journal: Int J Biomed Sci Date: 2016-09
Authors: Matheus F R A Oliveira; Walter E M Rocha; Julia D Soares; Victor M F S L'Armée; Mayara P G Martins; Aloísio M Rocha; Audes D M Feitosa; Ricardo C Lima; Pedro P M Oliveira; Lindemberg M Silveira-Filho; Otavio R Coelho-Filho; José R Matos-Souza; Orlando Petrucci; Andrei C Sposito; Wilson Nadruz Journal: Front Cardiovasc Med Date: 2022-01-21