Literature DB >> 20706756

The effect of lentivirus-mediated TH and GDNF genetic engineering mesenchymal stem cells on Parkinson's disease rat model.

Dezhi Shi1, Gong Chen, Li Lv, Lixin Li, Dong Wei, Peiyuan Gu, Juemin Gao, Yi Miao, Weixing Hu.   

Abstract

This study was designed to assess the potential therapeutic efficacy of gene-modified mesenchymal stem cells (MSCs), MSCs-TH and MSCs-GDNF, in PD rats. Fifty-nine PD rat models were divided into five groups and then the gene-modified MSCs were transplanted into the striatum of rats according to the design. Apomorphine-induced rotational behavior in rats was observed weekly; rats which received both MSCs-TH and MSCs-GDNF showed the most significant improvement compared with those in other groups (P < 0.01). Three weeks later, immunohistochemistry analysis found TH-positive cells and GDNF-positive cells in striatal. Eight weeks later, PD rats were killed. HPLC and ELISA results showed DA and GDNF content in striatum of rats which received both MSCs-TH, and MSCs-GDNF was considerably higher compared with those of other groups (P < 0.01),respectively. In conclusion, our results suggest that combined transplantation of MSCs expressing TH and GDNF can lead to remarkable therapeutic effects in a rat model of PD.

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Year:  2010        PMID： 20706756     DOI： 10.1007/s10072-010-0385-3

Source DB:  PubMed          Journal:  Neurol Sci        ISSN： 1590-1874            Impact factor:   3.307


  45 in total

1.  Transplantation of embryonic dopamine neurons for severe Parkinson's disease.

Authors:  C W Olanow; T Freeman; J Kordower
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2.  Recombinant adeno-associated viral vector-mediated glial cell line-derived neurotrophic factor gene transfer protects nigral dopamine neurons after onset of progressive degeneration in a rat model of Parkinson's disease.

Authors:  R J Mandel; R O Snyder; S E Leff
Journal:  Exp Neurol       Date:  1999-11       Impact factor: 5.330

3.  Fetal nigral grafts survive and mediate clinical benefit in a patient with Parkinson's disease.

Authors:  J H Kordower; T B Freeman; E Y Chen; E J Mufson; P R Sanberg; R A Hauser; B Snow; C W Olanow
Journal:  Mov Disord       Date:  1998-05       Impact factor: 10.338

4.  Hematopoietic cells differentiate into both microglia and macroglia in the brains of adult mice.

Authors:  M A Eglitis; E Mezey
Journal:  Proc Natl Acad Sci U S A       Date:  1997-04-15       Impact factor: 11.205

5.  Dopaminergic neurons protected from degeneration by GDNF gene therapy.

Authors:  D L Choi-Lundberg; Q Lin; Y N Chang; Y L Chiang; C M Hay; H Mohajeri; B L Davidson; M C Bohn
Journal:  Science       Date:  1997-02-07       Impact factor: 47.728

6.  Lentiviral vectors as a gene delivery system in the mouse midbrain: cellular and behavioral improvements in a 6-OHDA model of Parkinson's disease using GDNF.

Authors:  J C Bensadoun; N Déglon; J L Tseng; J L Ridet; A D Zurn; P Aebischer
Journal:  Exp Neurol       Date:  2000-07       Impact factor: 5.330

Review 7.  The role of deep brain stimulation as a surgical treatment for Parkinson's disease.

Authors:  C W Olanow; M F Brin; J A Obeso
Journal:  Neurology       Date:  2000       Impact factor: 9.910

8.  Adult bone marrow stromal cells in the embryonic brain: engraftment, migration, differentiation, and long-term survival.

Authors:  Guillermo Muñoz-Elias; Akiva J Marcus; Thomas M Coyne; Dale Woodbury; Ira B Black
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9.  Lentivirus-mediated transduction of islet grafts with interleukin 4 results in sustained gene expression and protection from insulitis.

Authors:  W S Gallichan; T Kafri; T Krahl; I M Verma; N Sarvetnick
Journal:  Hum Gene Ther       Date:  1998-12-10       Impact factor: 5.695

10.  Infection of human fetal cardiac myocytes by a human immunodeficiency virus-1-derived vector.

Authors:  M A Rebolledo; P Krogstad; F Chen; K M Shannon; T S Klitzner
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  10 in total

Review 1.  Concise Review: Using Stem Cells to Prevent the Progression of Myopia-A Concept.

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Authors:  Anup D Sharma; Pavel A Brodskiy; Emma M Petersen; Melih Dagdeviren; Eun-Ah Ye; Surya K Mallapragada; Donald Sakaguchi
Journal:  J Vis Exp       Date:  2015-01-04       Impact factor: 1.355

3.  The lentiviral-mediated Nurr1 genetic engineering mesenchymal stem cells protect dopaminergic neurons in a rat model of Parkinson's disease.

Authors:  Xiaoxiao Wang; Wenxin Zhuang; Wenyu Fu; Xiaocui Wang; E Lv; Fengjie Li; Shuanhu Zhou; Wolf-Dieter Rausch; Xin Wang
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Review 4.  Towards clinical application of mesenchymal stem cells for treatment of neurological diseases of the central nervous system.

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Journal:  J Neuroimmune Pharmacol       Date:  2013-04-12       Impact factor: 4.147

5.  The effect of lentivirus-mediated PSPN genetic engineering bone marrow mesenchymal stem cells on Parkinson's disease rat model.

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Journal:  PLoS One       Date:  2014-08-13       Impact factor: 3.240

6.  Targeted introduction and effective expression of hFIX at the AAVS1 locus in mesenchymal stem cells.

Authors:  Shu-Jun Li; Ying Luo; Le-Meng Zhang; Wei Yang; Guo-Gang Zhang
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7.  Widespread Striatal Delivery of GDNF from Encapsulated Cells Prevents the Anatomical and Functional Consequences of Excitotoxicity.

Authors:  Dwaine F Emerich; Jeffrey H Kordower; Yaping Chu; Chris Thanos; Briannan Bintz; Giovanna Paolone; Lars U Wahlberg
Journal:  Neural Plast       Date:  2019-03-11       Impact factor: 3.599

8.  Long-term, stable, targeted biodelivery and efficacy of GDNF from encapsulated cells in the rat and Goettingen miniature pig brain.

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9.  Delayed transplantation of precursor cell-derived astrocytes provides multiple benefits in a rat model of Parkinsons.

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Review 10.  Increased Understanding of Stem Cell Behavior in Neurodegenerative and Neuromuscular Disorders by Use of Noninvasive Cell Imaging.

Authors:  Bryan Holvoet; Liesbeth De Waele; Mattia Quattrocelli; Olivier Gheysens; Maurillio Sampaolesi; Catherine M Verfaillie; Christophe M Deroose
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  10 in total

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