Literature DB >> 20705931

Attitudes and beliefs of Michigan emergency physicians toward tissue plasminogen activator use in stroke: baseline survey results from the INcreasing Stroke Treatment through INteractive behavioral Change Tactic (INSTINCT) trial hospitals.

Phillip A Scott1, Zhenzhen Xu, William J Meurer, Shirley M Frederiksen, Mary N Haan, Michael W Westfall, Sandip U Kothari, Lewis B Morgenstern, John D Kalbfleisch.   

Abstract

BACKGROUND AND
PURPOSE: The objective of this study was to determine the baseline proportion of emergency physicians with favorable attitudes and beliefs toward intravenous tissue plasminogen activator (tPA) use in a cohort of randomly selected Michigan hospitals.
METHODS: Two hundred seventy-eight emergency physicians from 24 hospitals were surveyed. A confidential, self-administered, pilot-tested survey assessing demographics, practice environment, attitudes, and beliefs regarding tPA use in stroke was used. Main outcome measures assessed belief in a legal standard of care, likelihood of use in an ideal setting, comfort in use without a specialist consultation, and belief that science on tPA use is convincing. ORs with robust 95% CIs (adjusted for clustering) were calculated to quantify the association between responses and physician- and hospital-level characteristics.
RESULTS: One hundred ninety-nine surveys completed (gross response rate 71.6%). Ninety-nine percent (95% CI: 97.8 to 100) indicated use of tPA in eligible patients represented either acceptable or ideal patient care. Twenty-seven percent (95% CI: 21.7 to 32.3) indicated use of tPA represented a legal standard of care. Eighty-three percent (95% CI: 78.5 to 87.5) indicated they were "likely" or "very likely" to use tPA given an ideal setting. When asked about using tPA without a consultation, 65% (95% CI: 59.3 to 70.7) indicated they were uncomfortable. Forty-nine percent (95% CI: 43.0 to 55.0) indicated the science regarding use of tPA in stroke is convincing with 30% remaining neutral. Characteristics associated with favorable attitudes included non-emergency medicine board certification; older age, and a smaller hospital practice environment.
CONCLUSIONS: In this cohort, emergency physician attitudes and beliefs toward intravenous tPA use in stroke are considerably more favorable than previously reported.

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Year:  2010        PMID: 20705931      PMCID: PMC2935625          DOI: 10.1161/STROKEAHA.110.581942

Source DB:  PubMed          Journal:  Stroke        ISSN: 0039-2499            Impact factor:   7.914


  18 in total

1.  Use of tissue-type plasminogen activator for acute ischemic stroke: the Cleveland area experience.

Authors:  I L Katzan; A J Furlan; L E Lloyd; J I Frank; D L Harper; J A Hinchey; J P Hammel; A Qu; C A Sila
Journal:  JAMA       Date:  2000-03-01       Impact factor: 56.272

2.  Intravenous tissue-type plasminogen activator for treatment of acute stroke: the Standard Treatment with Alteplase to Reverse Stroke (STARS) study.

Authors:  G W Albers; V E Bates; W M Clark; R Bell; P Verro; S A Hamilton
Journal:  JAMA       Date:  2000-03-01       Impact factor: 56.272

3.  Survey of emergency physicians about recombinant tissue plasminogen activator for acute ischemic stroke.

Authors:  Devin L Brown; William G Barsan; Lynda D Lisabeth; Michael E Gallery; Lewis B Morgenstern
Journal:  Ann Emerg Med       Date:  2005-07       Impact factor: 5.721

4.  Thrombolysis with alteplase for acute ischaemic stroke in the Safe Implementation of Thrombolysis in Stroke-Monitoring Study (SITS-MOST): an observational study.

Authors:  Nils Wahlgren; Niaz Ahmed; Antoni Dávalos; Gary A Ford; Martin Grond; Werner Hacke; Michael G Hennerici; Markku Kaste; Sonja Kuelkens; Vincent Larrue; Kennedy R Lees; Risto O Roine; Lauri Soinne; Danilo Toni; Geert Vanhooren
Journal:  Lancet       Date:  2007-01-27       Impact factor: 79.321

Review 5.  Intravenous tissue plasminogen activator for acute ischemic stroke: A Canadian hospital's experience.

Authors:  K M Chapman; A R Woolfenden; D Graeb; D C Johnston; J Beckman; M Schulzer; P A Teal
Journal:  Stroke       Date:  2000-12       Impact factor: 7.914

6.  Intravenous tissue-type plasminogen activator therapy for ischemic stroke: Houston experience 1996 to 2000.

Authors:  J C Grotta; W S Burgin; A El-Mitwalli; M Long; M Campbell; L B Morgenstern; M Malkoff; A V Alexandrov
Journal:  Arch Neurol       Date:  2001-12

7.  Treatment with tissue plasminogen activator and inpatient mortality rates for patients with ischemic stroke treated in community hospitals.

Authors:  S D Reed; S C Cramer; D K Blough; K Meyer; J G Jarvik
Journal:  Stroke       Date:  2001-08       Impact factor: 7.914

8.  Acute stroke care in the US: results from 4 pilot prototypes of the Paul Coverdell National Acute Stroke Registry.

Authors:  Mathew J Reeves; Shalini Arora; Joseph P Broderick; Michael Frankel; John P Heinrich; Susan Hickenbottom; Herbert Karp; Kenneth A LaBresh; Ann Malarcher; G Mensah; Charles J Moomaw; Lee Schwamm; Paul Weiss
Journal:  Stroke       Date:  2005-05-12       Impact factor: 7.914

9.  Get With the Guidelines-Stroke is associated with sustained improvement in care for patients hospitalized with acute stroke or transient ischemic attack.

Authors:  Lee H Schwamm; Gregg C Fonarow; Mathew J Reeves; Wenqin Pan; Michael R Frankel; Eric E Smith; Gray Ellrodt; Christopher P Cannon; Li Liang; Eric Peterson; Kenneth A Labresh
Journal:  Circulation       Date:  2008-12-15       Impact factor: 29.690

10.  Thrombolysis with alteplase 3 to 4.5 hours after acute ischemic stroke.

Authors:  Werner Hacke; Markku Kaste; Erich Bluhmki; Miroslav Brozman; Antoni Dávalos; Donata Guidetti; Vincent Larrue; Kennedy R Lees; Zakaria Medeghri; Thomas Machnig; Dietmar Schneider; Rüdiger von Kummer; Nils Wahlgren; Danilo Toni
Journal:  N Engl J Med       Date:  2008-09-25       Impact factor: 91.245

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  10 in total

1.  Future neurohospitalist: teleneurohospitalist.

Authors:  William David Freeman; Kevin M Barrett; Kenneth A Vatz; Bart M Demaerschalk
Journal:  Neurohospitalist       Date:  2012-10

2.  Assessment of factors associated with prominent changes in blood pressure during an early mobilization protocol for patients with acute ischemic stroke after mechanical thrombectomy.

Authors:  Maiko Yagi; Sato Watanabe; Chika Kondo; Yukiko Kaihoko; Koji Endo; Fumio Miyashita; Tatsuro Takada; Toshihiro Ueda
Journal:  Phys Ther Res       Date:  2016-07-13

3.  Prevention of emergency physician migratory contamination in a cluster randomized trial to increase tissue plasminogen activator use in stroke (the INSTINCT trial).

Authors:  Victoria C Weston; William J Meurer; Shirley M Frederiksen; Allison K Fox; Phillip A Scott
Journal:  Am J Emerg Med       Date:  2014-09-06       Impact factor: 2.469

Review 4.  Intravenous Recombinant Tissue Plasminogen Activator Does Not Impact Mortality in Acute Ischemic Stroke at Any Time Point up to 6 Months: A Systematic Review and Meta-Analysis of Randomized Controlled Clinical Trials.

Authors:  Gyanendra Kumar; Drew Uhrig; Susan Fowler; Matthew C DeLaney; Andrei V Alexandrov
Journal:  CNS Drugs       Date:  2015-08       Impact factor: 5.749

5.  Protocol Deviations before and after Treatment with Intravenous Tissue Plasminogen Activator in Community Hospitals.

Authors:  Eric E Adelman; Phillip A Scott; Lesli E Skolarus; Allison K Fox; Shirley M Frederiksen; William J Meurer
Journal:  J Stroke Cerebrovasc Dis       Date:  2015-09-26       Impact factor: 2.136

6.  Agreement with evidence for tissue Plasminogen Activator use among emergency physicians: a cross-sectional survey.

Authors:  Alice M Grady; Jamie Bryant; Mariko L Carey; Christine L Paul; Rob W Sanson-Fisher; Christopher R Levi
Journal:  BMC Res Notes       Date:  2015-06-26

7.  Distance Neurological Supervision Using Telestroke Does Not Increase Door-to-Needle Time in Acute Ischemic Stroke Management: The Experience of Two Regional Stroke Units.

Authors:  Radhika Sood; Jean-Marie Annoni; Andrea M Humm; Ettore Accolla; Olivier Bill; Guillermo Toledo Sotomayor; Julien Niederhauser; Friedrich Medlin
Journal:  Front Neurol       Date:  2021-03-19       Impact factor: 4.003

8.  Analysis of Thrombolysis Process for Acute Ischemic Stroke in Urban and Rural Hospitals in Nova Scotia Canada.

Authors:  Tessa Bulmer; David Volders; Noreen Kamal
Journal:  Front Neurol       Date:  2021-03-15       Impact factor: 4.003

9.  tPA for Acute Ischemic Stroke and Its Controversies: A Review.

Authors:  Brian Dewar; Michel Shamy
Journal:  Neurohospitalist       Date:  2019-04-14

10.  Staff perspectives from Australian hospitals seeking to improve implementation of thrombolysis care for acute stroke.

Authors:  Christine Paul; Catherine D'Este; Annika Ryan; Amanda Jayakody; John Attia; Christopher Oldmeadow; Erin Kerr; Frans Henskens; Alice Grady; Christopher R Levi
Journal:  SAGE Open Med       Date:  2019-07-21
  10 in total

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