| Literature DB >> 20705368 |
Ahmed Kamal1, Rajesh V C R N C Shetti, Shaik Azeeza, S Kaleem Ahmed, P Swapna, A Malla Reddy, Inshad Ali Khan, Sandeep Sharma, Sheikh Tasduq Abdullah.
Abstract
In an effort to discover new and effective chemotherapeutic agents from this laboratory for the treatment of tuberculosis, here in we describe the synthesis and biological evaluation of a series of novel benzothiadiazine 1,1-dioxide (BTD) based congeners by using rifampicin, streptomycin; ciprofloxacin and amphotericin as positive controls. Further, to understand structural requirements for exploring the structure activity relationship of BTDs, cytotoxicity and in vivo study of recently reported potent molecule 4 (MIC = 1 microg/mL) is also discussed.Entities:
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Year: 2010 PMID： 20705368 DOI： 10.1016/j.ejmech.2010.07.015
Source DB: PubMed Journal: Eur J Med Chem ISSN： 0223-5234 Impact factor: 6.514