Literature DB >> 2070466

Formation of pyrazine derivatives from D-glucosamine and their deoxyribonucleic acid (DNA) strand breakage activity.

K Sumoto1, M Irie, N Mibu, S Miyano, Y Nakashima, K Watanabe, T Yamaguchi.   

Abstract

Two pyrazine derivatives [fructosazine (3) and deoxyfructosazine (6)] were simultaneously formed in a solution of D-glucosamine hydrochloride under various conditions. They showed deoxyribonucleic acid (DNA) strand breakage activity in plasmid pBR322 comparable to that of D-glucosamine. The DNA strand breakage by fructosazine (3) was stimulated by Cu2+.

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Year:  1991        PMID: 2070466     DOI: 10.1248/cpb.39.792

Source DB:  PubMed          Journal:  Chem Pharm Bull (Tokyo)        ISSN: 0009-2363            Impact factor:   1.645


  1 in total

1.  2,5-Deoxyfructosazine, a D-glucosamine derivative, inhibits T-cell interleukin-2 production better than D-glucosamine.

Authors:  Aiping Zhu; Ji-Biao Huang; Andrea Clark; Roberto Romero; Howard R Petty
Journal:  Carbohydr Res       Date:  2007-09-07       Impact factor: 2.104

  1 in total

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