Alstonia scholaris Linn R Br in the treatment and prevention of cancer: past, present, and future.

Alstonia scholaris, commonly known as devil's tree, is an important medicinal plant in the various folk and traditional systems of medicine in Asia, Australia, and Africa. The decoction, mostly prepared from the bark, is used to treat a variety of diseases of which the most important is malaria. Furthermore, ethnomedicinal practices also suggest it to be of use in treating cancer, and preclinical studies performed with cultured neoplastic cells and tumor-bearing animals having validated these observations. Additionally, the phytochemicals like echitamine, alstonine, pleiocarpamine, O-methylmacralstonine, macralstonine, and lupeol are also reported to possess antineoplastic effects. In addition to the cytotoxic effects, A scholaris is also observed to possess radiomodulatory, chemomodulatory, and chemopreventive effects and free-radical scavenging, antioxidant, anti-inflammatory, antimutagenic, and immunomodulatory activities, all of which are properties efficacious in the treatment and prevention of cancer. The current review for the first time summarizes the results related to these properties. An attempt is also made to address the lacunae in these published studies and emphasize aspects that need further investigations for it to be of use in clinics in the future.