Literature DB >> 20701588

HDAC inhibitors - new generation of target specific treatment.

A V Chavan1, R R Somani.   

Abstract

Histone Deacetylases (HDACs) enzymes are critical in regulating gene expression and transcription. They also play a fundamental role in regulating cellular activities such as cell proliferation, survival and differentiation. Inhibition of HDACs has generated many fascinating results including a new strategy in human cancer therapy. HDAC Inhibitors (HDACIs) like SAHA, TSA are emerging as new promising drugs for various anti-inflammatory and CNS-disorders. This review, along with chemical classification, emphasizes on the therapeutic potential of various HDACIs against different diseases.

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Year:  2010        PMID： 20701588     DOI： 10.2174/13895575110091263

Source DB:  PubMed          Journal:  Mini Rev Med Chem        ISSN： 1389-5575            Impact factor:   3.862


  20 in total

1.  Histone deacetylase (HDAC) inhibitor kinetic rate constants correlate with cellular histone acetylation but not transcription and cell viability.

Authors:  Benjamin E L Lauffer; Robert Mintzer; Rina Fong; Susmith Mukund; Christine Tam; Inna Zilberleyb; Birgit Flicke; Allegra Ritscher; Grazyna Fedorowicz; Roxanne Vallero; Daniel F Ortwine; Janet Gunzner; Zora Modrusan; Lars Neumann; Christopher M Koth; Patrick J Lupardus; Joshua S Kaminker; Christopher E Heise; Pascal Steiner
Journal:  J Biol Chem       Date:  2013-07-29       Impact factor: 5.157

Review 2.  How histone deacetylases control myelination.

Authors:  Claire Jacob; Frédéric Lebrun-Julien; Ueli Suter
Journal:  Mol Neurobiol       Date:  2011-08-23       Impact factor: 5.590

3.  Class I HDAC imaging using [ (3)H]CI-994 autoradiography.

Authors:  Yajie Wang; Yan-Ling Zhang; Krista Hennig; Jennifer P Gale; Yijia Hong; Anna Cha; Misha Riley; Florence Wagner; Stephen J Haggarty; Edward Holson; Jacob Hooker
Journal:  Epigenetics       Date:  2013-06-11       Impact factor: 4.528

Review 4.  HDAC inhibition in lupus models.

Authors:  Christopher M Reilly; Nicole Regna; Nilamadhab Mishra
Journal:  Mol Med       Date:  2011-02-11       Impact factor: 6.354

5.  Histone Deacetylase 1 (HDAC1) Negatively Regulates Thermogenic Program in Brown Adipocytes via Coordinated Regulation of Histone H3 Lysine 27 (H3K27) Deacetylation and Methylation.

Authors:  Fenfen Li; Rui Wu; Xin Cui; Lin Zha; Liqing Yu; Hang Shi; Bingzhong Xue
Journal:  J Biol Chem       Date:  2016-01-05       Impact factor: 5.157

6.  Interest of new alkylsulfonylhydrazide-type compound in the treatment of alcohol use disorders.

Authors:  Jérôme Jeanblanc; Erika Bourguet; Diana Sketriené; Céline Gonzalez; Gautier Moroy; Rémi Legastelois; Mathieu Létévé; Aurélie Trussardi-Régnier; Mickaël Naassila
Journal:  Psychopharmacology (Berl)       Date:  2018-04-30       Impact factor: 4.530

7.  Molecular mechanism of SAHA on regulation of autophagic cell death in tamoxifen-resistant MCF-7 breast cancer cells.

Authors:  Young Ju Lee; A Jin Won; Jaewon Lee; Jee H Jung; Sungpil Yoon; Byung Mu Lee; Hyung Sik Kim
Journal:  Int J Med Sci       Date:  2012-11-07       Impact factor: 3.738

Review 8.  Lysine acetylation: elucidating the components of an emerging global signaling pathway in trypanosomes.

Authors:  Victoria Lucia Alonso; Esteban Carlos Serra
Journal:  J Biomed Biotechnol       Date:  2012-10-03

9.  Re-engineering an alphoid(tetO)-HAC-based vector to enable high-throughput analyses of gene function.

Authors:  Artem V Kononenko; Nicholas C O Lee; William C Earnshaw; Natalay Kouprina; Vladimir Larionov
Journal:  Nucleic Acids Res       Date:  2013-04-04       Impact factor: 16.971

10.  Dynamic link between histone H3 acetylation and an increase in the functional characteristics of human ESC/iPSC-derived cardiomyocytes.

Authors:  Tomomi G Otsuji; Yuko Kurose; Hirofumi Suemori; Masako Tada; Norio Nakatsuji
Journal:  PLoS One       Date:  2012-09-12       Impact factor: 3.240
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