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Literature DB >> 20700144

New functions of aminoacyl-tRNA synthetases beyond translation.

Min Guo¹, Xiang-Lei Yang, Paul Schimmel.

Abstract

Over the course of evolution, eukaryotic aminoacyl-tRNA synthetases (aaRSs) progressively incorporated domains and motifs that have no essential connection to aminoacylation reactions. Their accretive addition to virtually all aaRSs correlates with the progressive evolution and complexity of eukaryotes. Based on recent experimental findings focused on a few of these additions and analysis of the aaRS proteome, we propose that they are markers for aaRS-associated functions beyond translation.

Entities: Chemical Disease Gene Species

Mesh：

Substances：

Year: 2010 PMID： 20700144 PMCID： PMC3042954 DOI： 10.1038/nrm2956

Source DB: PubMed Journal: Nat Rev Mol Cell Biol ISSN： 1471-0072 Impact factor: 94.444

65 in total

1. Two classes of tRNA synthetases suggested by sterically compatible dockings on tRNA acceptor stem.

Authors: L Ribas de Pouplana; P Schimmel
Journal: Cell Date: 2001-01-26 Impact factor: 41.582

Review 2. Aminoacyl-tRNA synthetases, the genetic code, and the evolutionary process.

Authors: C R Woese; G J Olsen; M Ibba; D Söll
Journal: Microbiol Mol Biol Rev Date: 2000-03 Impact factor: 11.056

3. Functional convergence of two lysyl-tRNA synthetases with unrelated topologies.

Authors: Takaho Terada; Osamu Nureki; Ryuichiro Ishitani; Alexandre Ambrogelly; Michael Ibba; Dieter Söll; Shigeyuki Yokoyama
Journal: Nat Struct Biol Date: 2002-04

4. Glutamine-dependent antiapoptotic interaction of human glutaminyl-tRNA synthetase with apoptosis signal-regulating kinase 1.

Authors: Y G Ko; E Y Kim; T Kim; H Park; H S Park; E J Choi; S Kim
Journal: J Biol Chem Date: 2000-11-28 Impact factor: 5.157

5. The appended C-domain of human methionyl-tRNA synthetase has a tRNA-sequestering function.

Authors: M Kaminska; V Shalak; M Mirande
Journal: Biochemistry Date: 2001-11-27 Impact factor: 3.162

6. Crystal structure of a human aminoacyl-tRNA synthetase cytokine.

Authors: Xiang-Lei Yang; Robert J Skene; Duncan E McRee; Paul Schimmel
Journal: Proc Natl Acad Sci U S A Date: 2002-11-11 Impact factor: 11.205

7. Induction of angiogenesis by a fragment of human tyrosyl-tRNA synthetase.

Authors: Keisuke Wakasugi; Bonnie M Slike; John Hood; Karla L Ewalt; David A Cheresh; Paul Schimmel
Journal: J Biol Chem Date: 2002-04-15 Impact factor: 5.157

8. A human aminoacyl-tRNA synthetase as a regulator of angiogenesis.

Authors: Keisuke Wakasugi; Bonnie M Slike; John Hood; Atsushi Otani; Karla L Ewalt; Martin Friedlander; David A Cheresh; Paul Schimmel
Journal: Proc Natl Acad Sci U S A Date: 2002-01-02 Impact factor: 11.205

9. Glycyl tRNA synthetase mutations in Charcot-Marie-Tooth disease type 2D and distal spinal muscular atrophy type V.

Authors: Anthony Antonellis; Rachel E Ellsworth; Nyamkhishig Sambuughin; Imke Puls; Annette Abel; Shih-Queen Lee-Lin; Albena Jordanova; Ivo Kremensky; Kyproula Christodoulou; Lefkos T Middleton; Kumaraswamy Sivakumar; Victor Ionasescu; Benoit Funalot; Jeffery M Vance; Lev G Goldfarb; Kenneth H Fischbeck; Eric D Green
Journal: Am J Hum Genet Date: 2003-04-10 Impact factor: 11.025

Review 10. Novel regulatory interactions and activities of mammalian tRNA synthetases.

Authors: Young-Gyu Ko; Heonyong Park; Sunghoon Kim
Journal: Proteomics Date: 2002-09 Impact factor: 3.984

157 in total

1. Linking energy production and protein synthesis in hydrogenotrophic methanogens.

Authors: Javin P Oza; Kevin R Sowers; John J Perona
Journal: Biochemistry Date: 2012-03-13 Impact factor: 3.162

2. Trp-tRNA synthetase bridges DNA-PKcs to PARP-1 to link IFN-γ and p53 signaling.

Authors: Mathew Sajish; Quansheng Zhou; Shuji Kishi; Delgado M Valdez; Mili Kapoor; Min Guo; Sunhee Lee; Sunghoon Kim; Xiang-Lei Yang; Paul Schimmel
Journal: Nat Chem Biol Date: 2012-04-15 Impact factor: 15.040

Review 3. Aminoacyl-tRNA synthetases and tumorigenesis: more than housekeeping.

Authors: Sunghoon Kim; Sungyong You; Daehee Hwang
Journal: Nat Rev Cancer Date: 2011-09-23 Impact factor: 60.716

4. Membrane anchoring of aminoacyl-tRNA synthetases by convergent acquisition of a novel protein domain.

Authors: Elvira Olmedo-Verd; Javier Santamaría-Gómez; Jesús A G Ochoa de Alda; Lluis Ribas de Pouplana; Ignacio Luque
Journal: J Biol Chem Date: 2011-09-30 Impact factor: 5.157

Review 5. When a common biological role does not imply common disease outcomes: Disparate pathology linked to human mitochondrial aminoacyl-tRNA synthetases.

Authors: Ligia Elena González-Serrano; Joseph W Chihade; Marie Sissler
Journal: J Biol Chem Date: 2019-01-15 Impact factor: 5.157

Review 6. Neurodegenerative Charcot-Marie-Tooth disease as a case study to decipher novel functions of aminoacyl-tRNA synthetases.

Authors: Na Wei; Qian Zhang; Xiang-Lei Yang
Journal: J Biol Chem Date: 2019-01-14 Impact factor: 5.157