Literature DB >> 20699565

Galangal pungent component, 1'-acetoxychavicol acetate, activates TRPA1.

Masataka Narukawa1, Kanako Koizumi, Yusaku Iwasaki, Kikue Kubota, Tatsuo Watanabe.   

Abstract

We investigated the activation of transient receptor potential cation channel (TRP) subfamily V, member 1 (TRPV1) and TRP subfamily A, member 1 (TRPA1) by 1'-acetoxychavicol acetate (ACA), the main pungent component in galangal. ACA did not activate TRPV1-expressing human embryonic kidney (HEK) cells, but strongly activated TRPA1-expressing HEK cells. ACA was more potent than allyl isothiocyanate, the typical TRPA1 agonist.

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Year:  2010        PMID： 20699565     DOI： 10.1271/bbb.100133

Source DB:  PubMed          Journal:  Biosci Biotechnol Biochem        ISSN： 0916-8451            Impact factor:   2.043


  8 in total

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Review 8.  Remedia Sternutatoria over the Centuries: TRP Mediation.

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  8 in total

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