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Literature DB >> 20697523

Severe Raynaud syndrome induced by adjuvant interferon alfa in metastatic melanoma.

H Husein-Elahmed¹, J L Callejas-Rubio, R Ortega Del Olmo, R Ríos-Fernandez, N Ortego-Centeno.

Abstract

Melanoma is the most lethal form of skin malignancy because of its aggressive behaviour. In advanced disease, interferon alfa can be used as adjuvant therapy. However, this therapy is not free of side effects. We present a case of severe Raynaud syndrome and digital necrosis induced by interferon alfa in a patient with melanoma. Pathogenic mechanisms are discussed.

Entities: Disease Species

Keywords: Melanoma; Raynaud syndrome; adjuvant; digital necrosis; interferon; treatment; vascular toxicity

Year: 2010 PMID： 20697523 PMCID： PMC2913821 DOI： 10.3747/co.v17i4.519

Source DB: PubMed Journal: Curr Oncol ISSN： 1198-0052 Impact factor: 3.677

12 in total

1. Digital vasculitis associated with interferon therapy.

Authors: T J Reid; F A Lombardo; J Redmond; S L Hammond; J A Coffey; H Ozer
Journal: Am J Med Date: 1992-06 Impact factor: 4.965

2. The Raynaud phenomenon and interferon therapy.

Authors: A Creutzig; L Caspary; M Freund
Journal: Ann Intern Med Date: 1996-09-01 Impact factor: 25.391

Review 3. Developing indications for the use of sentinel lymph node biopsy and adjuvant high-dose interferon alfa-2b in melanoma.

Authors: R W Dubois; S M Swetter; M Atkins; K McMasters; R Halbert; S J Miller; R Shiell; J Kirkwood
Journal: Arch Dermatol Date: 2001-09

Severe Raynaud syndrome induced by adjuvant interferon alfa in metastatic melanoma.

1. Digital vasculitis associated with interferon therapy.

2. The Raynaud phenomenon and interferon therapy.

Review 3. Developing indications for the use of sentinel lymph node biopsy and adjuvant high-dose interferon alfa-2b in melanoma.

4. Raynaud's phenomenon associated with alpha-interferon therapy.

5. [Raynaud syndrome complicated by digital gangrene during treatment with interferon-alpha].

6. High- and low-dose interferon alfa-2b in high-risk melanoma: first analysis of intergroup trial E1690/S9111/C9190.

7. Interferon-induced vasospasm in chronic myeloid leukaemia.

8. Severe Raynaud's syndrome associated with interferon therapy. A case history.

Review 9. Clinical toxicity of the interferons.

10. Adjuvant interferon alfa for melanoma: new evidence-based treatment recommendations?

Review 1. Drug-induced Raynaud's phenomenon: beyond β-adrenoceptor blockers.