BACKGROUND: Patients with cardiovascular disease (CVD) and chronic kidney disease (CKD) are at high risk of cardiovascular mortality, thus therapies to improve renal function should be clinically investigated. METHODS AND RESULTS: We divided consecutive patients with CVD and CKD (n=19) into exercise (n=10) and non-exercise (n=9) therapy groups. Exercise therapy for 12 weeks significantly improved the anaerobic metabolic threshold (AT-V O₂) and high-density lipoprotein cholesterol (HDL-C) levels, and reduced triglyceride levels. Exercise therapy also improved estimated glomerular filtration rate (eGFR). Change in eGFR correlated significantly and positively with change in AT-V O₂ and HDL-C, and negatively with change in triglyceride levels. CONCLUSIONS: Exercise therapy correlates with improving renal function in CVD patients with CKD through modifying lipid metabolism. Exercise therapy could be an effective clinical strategy to improve renal function.
BACKGROUND:Patients with cardiovascular disease (CVD) and chronic kidney disease (CKD) are at high risk of cardiovascular mortality, thus therapies to improve renal function should be clinically investigated. METHODS AND RESULTS: We divided consecutive patients with CVD and CKD (n=19) into exercise (n=10) and non-exercise (n=9) therapy groups. Exercise therapy for 12 weeks significantly improved the anaerobic metabolic threshold (AT-V O₂) and high-density lipoprotein cholesterol (HDL-C) levels, and reduced triglyceride levels. Exercise therapy also improved estimated glomerular filtration rate (eGFR). Change in eGFR correlated significantly and positively with change in AT-V O₂ and HDL-C, and negatively with change in triglyceride levels. CONCLUSIONS: Exercise therapy correlates with improving renal function in CVD patients with CKD through modifying lipid metabolism. Exercise therapy could be an effective clinical strategy to improve renal function.
Authors: Cassianne Robinson-Cohen; Alyson J Littman; Glen E Duncan; Noel S Weiss; Michael C Sachs; John Ruzinski; John Kundzins; Denise Rock; Ian H de Boer; T Alp Ikizler; Jonathan Himmelfarb; Bryan R Kestenbaum Journal: J Am Soc Nephrol Date: 2013-12-12 Impact factor: 10.121
Authors: Delphine S Tuot; Laura C Plantinga; Suzanne E Judd; Paul Muntner; Chi-Yuan Hsu; David G Warnock; Orlando M Gutiérrez; Monika Safford; Neil R Powe; William M McClellan Journal: Am J Nephrol Date: 2013-01-31 Impact factor: 3.754