Literature DB >> 2069573

Characterization of Porphyromonas (bacteroides) gingivalis hemagglutinin as a protease.

M Nishikata1, F Yoshimura.   

Abstract

A hemagglutinin (HA) was purified to homogeneity from the membrane fraction of the oral bacterium Porphyromonas gingivalis. The HA possessed protease activity hydrolyzing proteins and arginine-containing synthetic substrates. The protease activity was inhibited by thiol-blocking reagents, and hence the HA can be characterized as a cystein protease. The HA functions as an attachment factor and its substrate-binding site is responsible for the attachment to an erythrocyte.

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Year:  1991        PMID： 2069573     DOI： 10.1016/0006-291x(91)91819-x

Source DB:  PubMed          Journal:  Biochem Biophys Res Commun        ISSN： 0006-291X            Impact factor:   3.575


  23 in total

1.  Characterization of an adherence and antigenic determinant of the ArgI protease of Porphyromonas gingivalis which is present on multiple gene products.

Authors:  M A Curtis; J Aduse-Opoku; J M Slaney; M Rangarajan; V Booth; J Cridland; P Shepherd
Journal:  Infect Immun       Date:  1996-07       Impact factor: 3.441

2.  Activities of the Porphyromonas gingivalis PrtP proteinase determined by construction of prtP-deficient mutants and expression of the gene in Bacteroides species.

Authors:  G A Barkocy-Gallagher; J W Foley; M S Lantz
Journal:  J Bacteriol       Date:  1999-01       Impact factor: 3.490

3.  Inducible expression of a Porphyromonas gingivalis W83 membrane-associated protease.

Authors:  Y Park; B Lu; C Mazur; B C McBride
Journal:  Infect Immun       Date:  1997-03       Impact factor: 3.441

4.  The hemagglutinin gene A (hagA) of Porphyromonas gingivalis 381 contains four large, contiguous, direct repeats.

Authors:  N Han; J Whitlock; A Progulske-Fox
Journal:  Infect Immun       Date:  1996-10       Impact factor: 3.441

5.  Isolation and characterization of a minor fimbria from Porphyromonas gingivalis.

Authors:  N Hamada; H T Sojar; M I Cho; R J Genco
Journal:  Infect Immun       Date:  1996-11       Impact factor: 3.441

6.  Characterization of the tpr gene product and isolation of a specific protease-deficient mutant of Porphyromonas gingivalis W83.

Authors:  Y Park; B C McBride
Journal:  Infect Immun       Date:  1993-10       Impact factor: 3.441

7.  Porphyrin-mediated binding to hemoglobin by the HA2 domain of cysteine proteinases (gingipains) and hemagglutinins from the periodontal pathogen Porphyromonas gingivalis.

Authors:  A A DeCarlo; M Paramaesvaran; P L Yun; C Collyer; N Hunter
Journal:  J Bacteriol       Date:  1999-06       Impact factor: 3.490

8.  Selection and phenotypic characterization of nonhemagglutinating mutants of Porphyromonas gingivalis.

Authors:  F Chandad; D Mayrand; D Grenier; D Hinode; C Mouton
Journal:  Infect Immun       Date:  1996-03       Impact factor: 3.441

9.  Isolation and characterization of the Porphyromonas gingivalis prtT gene, coding for protease activity.

Authors:  J Otogoto; H K Kuramitsu
Journal:  Infect Immun       Date:  1993-01       Impact factor: 3.441

10.  The multiple forms of trypsin-like activity present in various strains of Porphyromonas gingivalis are due to the presence of either Arg-gingipain or Lys-gingipain.

Authors:  J Potempa; R Pike; J Travis
Journal:  Infect Immun       Date:  1995-04       Impact factor: 3.441
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